Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome

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Lovric , A , Graner , M , Bjornson , E , Arif , M , Benfeitas , R , Nyman , K , Ståhlman , M , Pentikäinen , M O , Lundbom , J , Hakkarainen , A , Siren , R , Nieminen , M S , Lundbom , N , Lauerma , K , Taskinen , M-R , Mardinoglu , A & Boren , J 2018 , ' Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome ' , Scientific Reports , vol. 8 , 14200 . https://doi.org/10.1038/s41598-018-31865-w

Titel: Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome
Författare: Lovric, Alen; Graner, Marit; Bjornson, Elias; Arif, Muhammad; Benfeitas, Rui; Nyman, Kristofer; Ståhlman, Marcus; Pentikäinen, Markku O.; Lundbom, Jesper; Hakkarainen, Antti; Siren, Reijo; Nieminen, Markku S.; Lundbom, Nina; Lauerma, Kirsi; Taskinen, Marja-Riitta; Mardinoglu, Adil; Boren, Jan
Upphovmannens organisation: HUS Heart and Lung Center
Department of Medicine
Marja-Riitta Taskinen Research Group
Clinicum
University of Helsinki
Kardiologian yksikkö
Department of Diagnostics and Therapeutics
HUS Medical Imaging Center
Department of General Practice and Primary Health Care
HUS Internal Medicine and Rehabilitation
Datum: 2018-09-21
Språk: eng
Sidantal: 14
Tillhör serie: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-018-31865-w
Permanenta länken (URI): http://hdl.handle.net/10138/248094
Abstrakt: Non-alcoholic fatty liver disease (NAFLD) is recognized as a liver manifestation of metabolic syndrome, accompanied with excessive fat accumulation in the liver and other vital organs. Ectopic fat accumulation was previously associated with negative effects at the systemic and local level in the human body. Thus, we aimed to identify and assess the predictive capability of novel potential metabolic biomarkers for ectopic fat depots in non-diabetic men with NAFLD, using the inflammation-associated proteome, lipidome and metabolome. Myocardial and hepatic triglycerides were measured with magnetic spectroscopy while function of left ventricle, pericardial and epicardial fat, subcutaneous and visceral adipose tissue were measured with magnetic resonance imaging. Measured ectopic fat depots were profiled and predicted using a Random Forest algorithm, and by estimating the Area Under the Receiver Operating Characteristic curves. We have identified distinct metabolic signatures of fat depots in the liver (TAG50:1, glutamate, diSM18:0 and CE20:3), pericardium (N-palmitoyl-sphinganine, HGF, diSM18:0, glutamate, and TNFSF14), epicardium (sphingomyelin, CE20:3, PC38:3 and TNFSF14), and myocardium (CE20:3, LAPTGF-beta 1, glutamate and glucose). Our analyses highlighted non-invasive biomarkers that accurately predict ectopic fat depots, and reflect their distinct metabolic signatures in subjects with NAFLD.
Subject: GROWTH-FACTOR 21
MYOCARDIAL TRIGLYCERIDE CONTENT
TYPE-2 DIABETES-MELLITUS
LIVER-DISEASE
INSULIN-RESISTANCE
CARDIOVASCULAR-DISEASE
MASS-SPECTROMETRY
ADIPOSE-TISSUE
CARDIAC STEATOSIS
SKELETAL-MUSCLE
3121 General medicine, internal medicine and other clinical medicine
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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