Kuopio birth cohort - design of a Finnish joint research effort for identification of environmental and lifestyle risk factors for the wellbeing of the mother and the newborn child

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Huuskonen , P , Keski-Nisula , L , Heinonen , S , Voutilainen , S , Tuomainen , T-P , Pekkanen , J , Lampi , J , Lehto , S M , Haaparanta , H , Elomaa , A-P , Voutilainen , R , Backman , K , Kokki , H , Kumpulainen , K , Paananen , J , Vähäkangas , K & Pasanen , M 2018 , ' Kuopio birth cohort - design of a Finnish joint research effort for identification of environmental and lifestyle risk factors for the wellbeing of the mother and the newborn child ' , BMC Pregnancy and Childbirth , vol. 18 , 381 . https://doi.org/10.1186/s12884-018-2013-9

Title: Kuopio birth cohort - design of a Finnish joint research effort for identification of environmental and lifestyle risk factors for the wellbeing of the mother and the newborn child
Author: Huuskonen, Pasi; Keski-Nisula, Leea; Heinonen, Seppo; Voutilainen, Sari; Tuomainen, Tomi-Pekka; Pekkanen, Juha; Lampi, Jussi; Lehto, Soili M.; Haaparanta, Hannariikka; Elomaa, Antti-Pekka; Voutilainen, Raimo; Backman, Katri; Kokki, Hannu; Kumpulainen, Kirsti; Paananen, Jussi; Vähäkangas, Kirsi; Pasanen, Markku
Contributor organization: Department of Obstetrics and Gynecology
Clinicum
Doctoral Programme in Clinical Research
University of Helsinki
Department of Public Health
Medicum
Department of Psychology and Logopedics
HUS Gynecology and Obstetrics
Date: 2018-09-21
Language: eng
Number of pages: 9
Belongs to series: BMC Pregnancy and Childbirth
ISSN: 1471-2393
DOI: https://doi.org/10.1186/s12884-018-2013-9
URI: http://hdl.handle.net/10138/248096
Abstract: Background: A Finnish joint research effort Kuopio Birth Cohort (KuBiCo) seeks to evaluate the effects of genetics, epigenetics and different risk factors (medication, nutrition, lifestyle factors and environmental aspects) during pregnancy on the somatic and psychological health status of the mother and the child. Methods: KuBiCo will ultimately include information on 10,000 mother-child pairs who have given their informed consent to participate in this cohort. Identification of foetal health risk factors that can potentially later manifest as disease requires a repository of relevant biological samples and a flexible open up-to-date data handling system to register, store and analyse biological, clinical and questionnaire-based data. KuBiCo includes coded questionnaire-based maternal background data gathered before, during and after the pregnancy and bio-banking of maternal and foetal samples that will be stored in deep freezers. Data from the questionnaires and biological samples will be collected into one electronic database. KuBiCo consists of several work packages which are complementary to each other: Maternal, foetal and placental metabolism and omits; Paediatrics; Mental wellbeing; Prenatal period and delivery; Analgesics and anaesthetics during peripartum period; Environmental effects; Nutrition; and Research ethics. Discussion: This report describes the set-up of the KuBiCo and descriptive analysis from 3532 parturients on response frequencies and feedback to KuBiCo questionnaires gathered from June 2012 to April 2016. Additionally, we describe basic demographic data of the participants (n = 1172). Based on the comparison of demographic data between official national statistics and our descriptive analysis, KuBiCo represents a cross-section of Finnish pregnant women.
Subject: Birth weight
Environmental health
Foetus
Maternal smoking
Mental health
Metabolism
Nutrition
Paediatrics
Placenta
Research ethics
PREGNANCY
EXPOSURE
DISEASES
SMOKING
CANCER
HEALTH
RATIO
3123 Gynaecology and paediatrics
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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