The Gut-Kidney Axis : Putative Interconnections Between Gastrointestinal and Renal Disorders

Show full item record



Permalink

http://hdl.handle.net/10138/248097

Citation

Lehto , M & Groop , P-H 2018 , ' The Gut-Kidney Axis : Putative Interconnections Between Gastrointestinal and Renal Disorders ' , Frontiers in Endocrinology , vol. 9 , 553 . https://doi.org/10.3389/fendo.2018.00553

Title: The Gut-Kidney Axis : Putative Interconnections Between Gastrointestinal and Renal Disorders
Author: Lehto, Markku; Groop, Per-Henrik
Contributor: University of Helsinki, Doctoral Programme in Clinical Research
University of Helsinki, Doctoral Programme in Clinical Research
Date: 2018-09-19
Language: eng
Number of pages: 11
Belongs to series: Frontiers in Endocrinology
ISSN: 1664-2392
URI: http://hdl.handle.net/10138/248097
Abstract: Diabetic kidney disease (DKD) is a devastating condition associated with increased morbidity and premature mortality. The etiology of DKD is still largely unknown. However, the risk of DKD development and progression is most likely modulated by a combination of genetic and environmental factors. Patients with autoimmune diseases, like type 1 diabetes, inflammatory bowel disease, and celiac disease, share some genetic background. Furthermore, gastrointestinal disorders are associated with an increased risk of kidney disease, although the true mechanisms have still to be elucidated. Therefore, the principal aim of this review is to evaluate the impact of disturbances in the gastrointestinal tract on the development of renal disorders.
Subject: type 1 diabetes
diabetic nephropathy
chronic kidney disease
gut permeability
inflammatory bowel disease
gastrointestinal inflammation
contact activation
intestinal alkaline phosphatase
INFLAMMATORY-BOWEL-DISEASE
INTESTINAL ALKALINE-PHOSPHATASE
FECAL MICROBIOTA TRANSPLANTATION
TYPE-1 DIABETES-MELLITUS
KALLIKREIN-KININ SYSTEM
GENETICALLY SUSCEPTIBLE RATS
NORMAL C1 INHIBITOR
DSS-INDUCED COLITIS
HEREDITARY ANGIOEDEMA
CELIAC-DISEASE
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
fendo_09_00553.pdf 896.2Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record