Marine Microalgae: Promising Source for New Bioactive Compounds

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de Vera , C R , Díaz Crespín , G , Hernández Daranas , A , Montalvão Looga , S , Lillsunde , K-E , Tammela , P , Perälä , M , Hongisto , V , Virtanen , J , Rischer , H , Muller , C D , Norte , M , Fernández , J J & Souto , M L 2018 , ' Marine Microalgae: Promising Source for New Bioactive Compounds ' , Marine Drugs , vol. 16 , no. 9 , 317 .

Title: Marine Microalgae: Promising Source for New Bioactive Compounds
Author: de Vera, Caterina R.; Díaz Crespín, Guillermo; Hernández Daranas, Antonio; Montalvão Looga, Sofia; Lillsunde, Katja-Emilia; Tammela, Päivi; Perälä, Merja; Hongisto, Vesa; Virtanen, Johannes; Rischer, Heiko; Muller, Christian D.; Norte, Manuel; Fernández, José J.; Souto, María L.
Contributor organization: Faculty of Pharmacy
Division of Pharmaceutical Biosciences
Drug Research Program
Bioactivity Screening Group
Date: 2018-09-06
Language: eng
Number of pages: 12
Belongs to series: Marine Drugs
ISSN: 1660-3397
Abstract: The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine cell factories for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexandrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae.
Subject: 317 Pharmacy
blue biotechnology
marine microalgae
bioactive compound
drug discovery
marine natural products
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion
Grant number: 277001

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