Statin Treatment Is Associated With a Neutral Effect on Health-Related Quality of Life Among Community-Dwelling Octogenarian Men : The Helsinki Businessmen Study

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Strandberg , T E , Urtamo , A , Kähärä , J , Strandberg , A Y , Pitkälä , K H & Kautiainen , H 2018 , ' Statin Treatment Is Associated With a Neutral Effect on Health-Related Quality of Life Among Community-Dwelling Octogenarian Men : The Helsinki Businessmen Study ' , Journals of Gerontology. Series A: Biological Sciences and Medical Sciences , vol. 73 , no. 10 , pp. 1418-1423 . https://doi.org/10.1093/gerona/gly073

Title: Statin Treatment Is Associated With a Neutral Effect on Health-Related Quality of Life Among Community-Dwelling Octogenarian Men : The Helsinki Businessmen Study
Author: Strandberg, Timo E.; Urtamo, Annele; Kähärä, Juuso; Strandberg, Arto Y.; Pitkälä, Kaisu H.; Kautiainen, Hannu
Contributor: University of Helsinki, Timo Strandberg / Principal Investigator
University of Helsinki, Clinicum
University of Helsinki, Department of General Practice and Primary Health Care
Date: 2018-10
Language: eng
Number of pages: 6
Belongs to series: Journals of Gerontology. Series A: Biological Sciences and Medical Sciences
ISSN: 1079-5006
URI: http://hdl.handle.net/10138/250559
Abstract: Background: Statin treatment is common among 80+ people, but little is known about statin effects on health-related quality of life (HRQoL) in this oldest age group. Methods: In the Helsinki Businessmen Study (HBS), men born from 1919 to 1934 (original n = 3,490), have been followed-up since the 1960s. In 2015, a questionnaire about lifestyle, diseases, and medications, and including RAND-36/SF-36 HRQoL instrument was mailed to survivors. About 612 men (72.6%) responded, 530 of them reporting their medications (98% community-living). Propensity score analysis was used to compare statin users and nonusers for HRQoL. Results: We compared 229 current statin users (median age 85 years, interquartile range 84-88 years) with 301 nonusers (86; 84-89 years). Current statin users had had significantly higher serum cholesterol level in midlife (p <.001), but current lifestyle-related characteristics were similar in users and nonusers. Statin users reported more hypertension (61.1%, p <.001), diabetes (23.6%, p Conclusions: Our study suggests that statin treatment has no significant effect on health-related quality of life among octogenarian, community-dwelling men. The results contradict concerns about statin treatment in the oldest-old, and may caution against deprescribing of statins due to old age alone.
Subject: Quality of life
Statin treatment
SF-36
Multimorbidities
Drug-related
Frailty
PRIMARY PREVENTION
ELDERLY ADULTS
OLDER PATIENTS
LIMITING ILLNESS
MORTALITY
THERAPY
DISEASE
FRAILTY
MIDLIFE
SAFETY
3121 General medicine, internal medicine and other clinical medicine
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