Estimation of Arterial Carbon Dioxide Based on End-Tidal Gas Pressure and Oxygen Saturation

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Rentola , R , Hästbacka , J , Heinonen , E , Rosenberg , P H , Häggblom , T & Skrifvars , M B 2018 , ' Estimation of Arterial Carbon Dioxide Based on End-Tidal Gas Pressure and Oxygen Saturation ' , Journal of clinical medicine , vol. 7 , no. 9 , 290 .

Titel: Estimation of Arterial Carbon Dioxide Based on End-Tidal Gas Pressure and Oxygen Saturation
Författare: Rentola, Raisa; Hästbacka, Johanna; Heinonen, Erkki; Rosenberg, Per H.; Häggblom, Tom; Skrifvars, Markus B.
Upphovmannens organisation: Anestesiologian yksikkö
HUS Perioperative, Intensive Care and Pain Medicine
Department of Diagnostics and Therapeutics
University of Helsinki
HUS Emergency Medicine and Services
Datum: 2018-09
Språk: eng
Sidantal: 11
Tillhör serie: Journal of clinical medicine
ISSN: 2077-0383
Permanenta länken (URI):
Abstrakt: Arterial blood gas (ABG) analysis is the traditional method for measuring the partial pressure of carbon dioxide. In mechanically ventilated patients a continuous noninvasive monitoring of carbon dioxide would obviously be attractive. In the current study, we present a novel formula for noninvasive estimation of arterial carbon dioxide. Eighty-one datasets were collected from 19 anesthetized and mechanically ventilated pigs. Eleven animals were mechanically ventilated without interventions. In the remaining eight pigs the partial pressure of carbon dioxide was manipulated. The new formula (Formula 1) is PaCO2 = PETCO2 + k(PETO2 - PaO2) where PaO2 was calculated from the oxygen saturation. We tested the agreements of this novel formula and compared it to a traditional method using the baseline PaCO2 - ETCO2 gap added to subsequently measured, end-tidal carbon dioxide levels (Formula 2). The mean difference between PaCO2 and calculated carbon dioxide (Formula 1) was 0.16 kPa (+/- SE 1.17). The mean difference between PaCO2 and carbon dioxide with Formula 2 was 0.66 kPa (+/- SE 0.18). With a mixed linear model excluding cases with cardiorespiratory collapse, there was a significant difference between formulae (p <0.001), as well as significant interaction between formulae and time (p <0.001). In this preliminary animal study, this novel formula appears to have a reasonable agreement with PaCO2 values measured with ABG analysis, but needs further validation in human patients.
Subject: arterial carbon dioxide
mechanical ventilation
noninvasive measurement
blood gas analysis
3126 Surgery, anesthesiology, intensive care, radiology
3121 General medicine, internal medicine and other clinical medicine
Referentgranskad: Ja
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion

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