Estimation of Arterial Carbon Dioxide Based on End-Tidal Gas Pressure and Oxygen Saturation

Show simple item record Rentola, Raisa Hästbacka, Johanna Heinonen, Erkki Rosenberg, Per H. Häggblom, Tom Skrifvars, Markus B. 2018-10-17T07:10:01Z 2018-10-17T07:10:01Z 2018-09
dc.identifier.citation Rentola , R , Hästbacka , J , Heinonen , E , Rosenberg , P H , Häggblom , T & Skrifvars , M B 2018 , ' Estimation of Arterial Carbon Dioxide Based on End-Tidal Gas Pressure and Oxygen Saturation ' , Journal of clinical medicine , vol. 7 , no. 9 , 290 .
dc.identifier.other PURE: 116975558
dc.identifier.other PURE UUID: 70d9d357-aa79-4720-91b4-a91bf76e9372
dc.identifier.other WOS: 000445635800064
dc.identifier.other ORCID: /0000-0002-3613-7231/work/49702929
dc.description.abstract Arterial blood gas (ABG) analysis is the traditional method for measuring the partial pressure of carbon dioxide. In mechanically ventilated patients a continuous noninvasive monitoring of carbon dioxide would obviously be attractive. In the current study, we present a novel formula for noninvasive estimation of arterial carbon dioxide. Eighty-one datasets were collected from 19 anesthetized and mechanically ventilated pigs. Eleven animals were mechanically ventilated without interventions. In the remaining eight pigs the partial pressure of carbon dioxide was manipulated. The new formula (Formula 1) is PaCO2 = PETCO2 + k(PETO2 - PaO2) where PaO2 was calculated from the oxygen saturation. We tested the agreements of this novel formula and compared it to a traditional method using the baseline PaCO2 - ETCO2 gap added to subsequently measured, end-tidal carbon dioxide levels (Formula 2). The mean difference between PaCO2 and calculated carbon dioxide (Formula 1) was 0.16 kPa (+/- SE 1.17). The mean difference between PaCO2 and carbon dioxide with Formula 2 was 0.66 kPa (+/- SE 0.18). With a mixed linear model excluding cases with cardiorespiratory collapse, there was a significant difference between formulae (p <0.001), as well as significant interaction between formulae and time (p <0.001). In this preliminary animal study, this novel formula appears to have a reasonable agreement with PaCO2 values measured with ABG analysis, but needs further validation in human patients. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Journal of clinical medicine
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject arterial carbon dioxide
dc.subject mechanical ventilation
dc.subject noninvasive measurement
dc.subject blood gas analysis
dc.subject BLOOD-GAS
dc.subject INJURY
dc.subject ADULTS
dc.subject PCO2
dc.subject ICU
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Estimation of Arterial Carbon Dioxide Based on End-Tidal Gas Pressure and Oxygen Saturation en
dc.type Article
dc.contributor.organization Anestesiologian yksikkö
dc.contributor.organization HUS Perioperative, Intensive Care and Pain Medicine
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Clinicum
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Emergency Medicine and Services
dc.description.reviewstatus Peer reviewed
dc.relation.issn 2077-0383
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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