The Potential of Gut Commensals in Reinforcing Intestinal Barrier Function and Alleviating Inflammation

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Hiippala , K , Jouhten , H , Ronkainen , A , Hartikainen , A , Kainulainen , V , Jalanka , J & Satokari , R 2018 , ' The Potential of Gut Commensals in Reinforcing Intestinal Barrier Function and Alleviating Inflammation ' , Nutrients , vol. 10 , no. 8 , 988 . https://doi.org/10.3390/nu10080988

Title: The Potential of Gut Commensals in Reinforcing Intestinal Barrier Function and Alleviating Inflammation
Author: Hiippala, Kaisa; Jouhten, Hanne; Ronkainen, Aki; Hartikainen, Anna; Kainulainen, Veera; Jalanka, Jonna; Satokari, Reetta
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Research Programs Unit
University of Helsinki, Research Programs Unit
University of Helsinki, Research Programs Unit
University of Helsinki, Medicum
University of Helsinki, Research Programs Unit
University of Helsinki, Reetta Maria Satokari / Principal Investigator
Date: 2018-08
Language: eng
Number of pages: 23
Belongs to series: Nutrients
ISSN: 2072-6643
URI: http://hdl.handle.net/10138/250888
Abstract: The intestinal microbiota, composed of pro- and anti-inflammatory microbes, has an essential role in maintaining gut homeostasis and functionality. An overly hygienic lifestyle, consumption of processed and fiber-poor foods, or antibiotics are major factors modulating the microbiota and possibly leading to longstanding dysbiosis. Dysbiotic microbiota is characterized to have altered composition, reduced diversity and stability, as well as increased levels of lipopolysaccharide-containing, proinflammatory bacteria. Specific commensal species as novel probiotics, so-called next-generation probiotics, could restore the intestinal health by means of attenuating inflammation and strengthening the epithelial barrier. In this review we summarize the latest findings considering the beneficial effects of the promising commensals across all major intestinal phyla. These include the already well-known bifidobacteria, which use extracellular structures or secreted substances to promote intestinal health. Faecalibacterium prausnitzii, Roseburia intestinalis, and Eubacterium hallii metabolize dietary fibers as major short-chain fatty acid producers providing energy sources for enterocytes and achieving anti-inflammatory effects in the gut. Akkermansia muciniphila exerts beneficial action in metabolic diseases and fortifies the barrier function. The health-promoting effects of Bacteroides species are relatively recently discovered with the findings of excreted immunomodulatory molecules. These promising, unconventional probiotics could be a part of biotherapeutic strategies in the future.
Subject: 3111 Biomedicine
3141 Health care science
commensal bacteria
intestinal health
next generation probiotics
dysbiosis
intestinal permeability
butyrate producing bacteria
anti-inflammatory
BUTYRATE-PRODUCING BACTERIA
ESCHERICHIA-COLI NISSLE
FECAL MICROBIOTA TRANSPLANTATION
CROSS-FEEDING INTERACTIONS
FAECALIBACTERIUM-PRAUSNITZII
AKKERMANSIA-MUCINIPHILA
BOWEL-DISEASE
ULCERATIVE-COLITIS
HUMAN FECES
IN-VITRO
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