Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

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Million Vet Program 2018 , ' Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits ' , Nature Genetics , vol. 50 , no. 10 , pp. 1412-+ . https://doi.org/10.1038/s41588-018-0205-x

Title: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Author: Million Vet Program
Date: 2018-10
Language: eng
Number of pages: 17
Belongs to series: Nature Genetics
ISSN: 1061-4036
URI: http://hdl.handle.net/10138/251517
Abstract: High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
Subject: GENOME-WIDE ASSOCIATION
CARDIOVASCULAR-DISEASE RISK
UK BIOBANK
HYPERTENSION
VARIANTS
METAANALYSIS
COMMON
HEALTH
RARE
HYPERALDOSTERONISM
3111 Biomedicine
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