Plasma enterolactone and risk of prostate cancer in middle-aged Swedish men

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http://hdl.handle.net/10138/251529

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Wallström , P , Drake , I , Sonestedt , E , Gullberg , B , Bjartell , A , Olsson , H , Adlercreutz , H , Tikkanen , M J & Wirfält , E 2018 , ' Plasma enterolactone and risk of prostate cancer in middle-aged Swedish men ' , European Journal of Nutrition , vol. 57 , no. 7 , pp. 2595-2606 . https://doi.org/10.1007/s00394-017-1530-z

Title: Plasma enterolactone and risk of prostate cancer in middle-aged Swedish men
Author: Wallström, Peter; Drake, Isabel; Sonestedt, Emily; Gullberg, Bo; Bjartell, Anders; Olsson, Håkan; Adlercreutz, Herman; Tikkanen, Matti J.; Wirfält, Elisabet
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2018-10
Language: eng
Number of pages: 12
Belongs to series: European Journal of Nutrition
ISSN: 1436-6207
URI: http://hdl.handle.net/10138/251529
Abstract: Enterolactone (ENL) is formed in the human gut after consumption of lignans, has estrogenic properties, and has been associated with risk of prostate cancer. We examined the association between plasma ENL levels and prostate cancer in a nested case-control study within the population-based Malmo Diet and Cancer cohort. We also examined the association between plasma ENL and dietary and lifestyle factors. The study population consisted of 1010 cases occurring during a mean follow-up of 14.6 years, and 1817 controls matched on age and study entry date. We used national registers (95%) and hospital records (5%) to ascertain cases. Diet was estimated by a modified diet history method. Plasma ENL concentrations were determined by a time-resolved fluoroimmunoassay. Odds ratios were calculated by unconditional logistic regression. There were no significant associations between plasma ENL and incidence of all prostate cancer (odds ratio 0.99 [95% confidence interval 0.77-1.280] for the highest ENL quintile versus lowest, p for trend 0.66). However, in certain subgroups of men, including men with abdominal obesity (p for interaction = 0.012), we observed associations between high ENL levels and lower odds of high-risk prostate cancer. Plasma ENL was positively associated with consumption of high-fibre bread, fruit, tea, and coffee; with age, and with height, while it was negatively associated with smoking and waist circumference; however, although significant, all associations were rather weak (r ae |0.14|). ENL concentration was not consistently associated with lower prostate cancer risk, although it was weakly associated with a healthy lifestyle.
Subject: Diet
Prostate cancer
Nested case-control
Lignans
Enterolactone
NESTED CASE-CONTROL
TIME-RESOLVED FLUOROIMMUNOASSAY
SINGLE-NUCLEOTIDE POLYMORPHISMS
FOOD FREQUENCY QUESTIONNAIRE
DIET HISTORY METHOD
SERUM ENTEROLACTONE
MALMO DIET
BREAST-CANCER
PHYTO-ESTROGENS
COHORT
3122 Cancers
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