Antibacterial Bioactive Glass, S53P4, for Chronic Bone Infections - A Multinational Study

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Lindfors , N , Geurts , J , Drago , L , Arts , J J , Juutilainen , V , Hyvönen , P , Suda , A J , Domenico , A , Artiaco , S , Alizadeh , C , Brychcy , A , Bialecki , J & Romano , C L 2017 , Antibacterial Bioactive Glass, S53P4, for Chronic Bone Infections - A Multinational Study . in L Drago (ed.) , MODERN APPROACH TO BIOFILM-RELATED ORTHOPAEDIC IMPLANT INFECTIONS: ADVANCES IN MICROBIOLOGY, INFECTIOUS DISEASES AND PUBLIC HEALTH, VOL 5 . Advances in Experimental Medicine and Biology , vol. 971 , Springer International Publishing AG , pp. 81-92 . https://doi.org/10.1007/5584_2016_156

Title: Antibacterial Bioactive Glass, S53P4, for Chronic Bone Infections - A Multinational Study
Author: Lindfors, Nina; Geurts, Jan; Drago, Lorenzo; Arts, J. J.; Juutilainen, Vesa; Hyvönen, Pekka; Suda, Arnold J.; Domenico, Aloj; Artiaco, Stefano; Alizadeh, Chingiz; Brychcy, Adrian; Bialecki, Jertzy; Romano, Carlo L.
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Plastiikkakirurgian yksikkö
Drago, Lorenzo





Publisher: Springer International Publishing AG
Date: 2017
Language: eng
Number of pages: 12
Belongs to series: MODERN APPROACH TO BIOFILM-RELATED ORTHOPAEDIC IMPLANT INFECTIONS: ADVANCES IN MICROBIOLOGY, INFECTIOUS DISEASES AND PUBLIC HEALTH, VOL 5
Belongs to series: Advances in Experimental Medicine and Biology
ISBN: 978-3-319-52273-9
978-3-319-52274-6
DOI: https://doi.org/10.1007/5584_2016_156
URI: http://hdl.handle.net/10138/252437
Abstract: Osteomyelitis is an infectious process in bone that occasionally leads to bone destruction. Traditionally, the surgical treatment procedure is performed in combination with systemic and local antibiotics as a two-stage procedure that uses autograft or allograft bone for filling of the cavitary defect. Bioactive glass (BAG-S53P4) is a bone substitute with proven antibacterial and bone bonding properties. One hundred and sixteen patients who had verified chronic osteomyelitis was treated using BAG-S53P4 as part of the treatment. Most of the patients had previously undergone numerous procedures, sometimes for decades. A register of patient data obtained from 11 centers from Finland, Italy, the Netherlands, Germany, Azerbaijan and Poland was set-up and continuously maintained at Helsinki University Central Hospital. The location of the osteomyelitis was mainly in the tibia followed by the femur and then the calcaneus. The median age of the patients was 48 years (15-87). The patients were either treated according to a one-stage procedure without local antibiotics (85 %) or by a two-stage procedure using antibiotic beads in the first procedure (15 %). The minimum follow-up was 1 year (12-95 months, median 31). The cure rate was 104/116, the total success rate 90 % and most of the patients showed a rapid recovery. The study shows that (BAG-S53P4) can be used in a one-stage procedure in treatment of osteomyelitis with excellent results.
Subject: Bioactive glass
S53P4
Osteomyelitis
Antibacterial
Bone substitute
TIBIAL PLATEAU FRACTURES
AUTOGENOUS BONE
FOLLOW-UP
IN-VITRO
GRAFT SUBSTITUTES
OSTEOMYELITIS
SPONDYLODESIS
OBLITERATION
GRANULES
BACTERIA
3111 Biomedicine
3142 Public health care science, environmental and occupational health
3121 General medicine, internal medicine and other clinical medicine
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