Metronidazole and ursodeoxycholic acid for primary sclerosing cholangitis : A randomized placebo-controlled trial

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Färkkilä , M , Karvonen , A-L , Nurmi , H , Nuutinen , H , Taavitsainen , M , Pikkarainen , P & Kärkkäinen , P 2004 , ' Metronidazole and ursodeoxycholic acid for primary sclerosing cholangitis : A randomized placebo-controlled trial ' , Hepatology , vol. 40 , no. 6 , pp. 1379-1386 . https://doi.org/10.1002/hep.20457

Title: Metronidazole and ursodeoxycholic acid for primary sclerosing cholangitis : A randomized placebo-controlled trial
Author: Färkkilä, Martti; Karvonen, Anna-Liisa; Nurmi, Heimo; Nuutinen, Hannu; Taavitsainen, Matti; Pikkarainen, Pekka; Kärkkäinen, Päivi
Contributor: University of Helsinki, Gastroenterologian yksikkö
University of Helsinki, Gastroenterologian yksikkö
University of Helsinki, Department of Pathology
Date: 2004-12
Language: eng
Number of pages: 8
Belongs to series: Hepatology
ISSN: 0270-9139
URI: http://hdl.handle.net/10138/252757
Abstract: No effective medical therapy is currently available for primary sclerosing cholangitis (PSC). Ursodeoxycholic acid (UDCA) improves liver enzymes, but its effect on liver histology is controversial. Metronidazole (MTZ) prevents PSC-like liver damage in animal models and reduces intestinal permeability. We recruited 80 patients with PSC into a randomized placebo-controlled study to evaluate the effect of UDCA and MTZ (UDCA/MTZ) compared with UDCA/placebo on the progression of PSC. Patients (41 UDCA/placebo and 39 UDCA/ MTZ) were followed every third month. Assessment of liver function test, histological stage and grade, and cholangiography (via ERCP) at baseline showed no differences between the groups. After 36 months, serum aminotransferases gamma-glutamyltransferase, and alkaline phosphatase (ALP) decreased markedly in both groups, serum ALP more significantly in the UDCA/MTZ group (-337 +/- 54 U/L, P
Subject: PRIMARY BILIARY-CIRRHOSIS
BOWEL BACTERIAL OVERGROWTH
NATURAL-HISTORY
CLASS-I
THERAPY
METHOTREXATE
EXPRESSION
LIVER
RATS
CHOLANGIOGRAPHY
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