Immune activation in the small intestine in patients with rheumatoid arthritis

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Nissinen , R , Leirisalo-Repo , M , Nieminen , A M , Halme , L , Färkkilä , M , Palosuo , T & Vaarala , O 2004 , ' Immune activation in the small intestine in patients with rheumatoid arthritis ' , Annals of the Rheumatic Diseases , vol. 63 , no. 10 , pp. 1327-1330 . https://doi.org/10.1136/ard.2003.011304

Title: Immune activation in the small intestine in patients with rheumatoid arthritis
Author: Nissinen, R.; Leirisalo-Repo, M; Nieminen, A. M.; Halme, L.; Färkkilä, M.; Palosuo, T.; Vaarala, O.
Contributor: University of Helsinki, Department of Medicine
University of Helsinki, II kirurgian klinikka
University of Helsinki, Gastroenterologian yksikkö
University of Helsinki, National Public Health Institute
Date: 2004-10
Language: eng
Number of pages: 4
Belongs to series: Annals of the Rheumatic Diseases
ISSN: 0003-4967
URI: http://hdl.handle.net/10138/252758
Abstract: Objectives: To determine whether inflammation in the gut associated immune system is activated in rheumatoid arthritis ( RA). The expression of chemokine receptor- (CCR4, CCR5) and cytokine- ( interleukin (IL) 2, IL10, interferon gamma (IFNgamma), tumour necrosis factor alpha (TNFalpha), and transforming growth factor beta (TGFbeta)) specific mRNA in intestinal biopsy samples from patients with RA was examined. Methods: Duodenal biopsy samples from 13 patients with RA and 15 control subjects were studied. The mRNA expression of CCR4, CCR5, IL2, IL10, IFNgamma, TNFalpha, and TGFb in intestinal biopsy samples was demonstrated by real time quantitative reverse transcriptase-polymerase chain reaction. Results: The mRNA expression of CCR4, CCR5, and IL10 in intestinal biopsy samples was increased in patients with RA in comparison with control subjects ( p = 0.001, p = 0.046, p = 0.019). No difference in the expression levels of IL2, IFNgamma, TNFalpha, or TGFbeta was seen between patients with RA and controls. Conclusions: The increased intestinal mRNA expression of IL10, CCR5, and CCR4 suggests that gut associated immune cells are activated in patients with RA.
Subject: INFLAMMATORY-BOWEL-DISEASE
T-CELLS
INTRAEPITHELIAL LYMPHOCYTES
EXPRESSION
CHEMOKINES
RECEPTORS
CYTOKINE
ETIOLOGY
MICE
LUNG
3121 General medicine, internal medicine and other clinical medicine
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