Familial risks of ovarian cancer by age at diagnosis, proband type and histology

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Zheng , G , Yu , H , Kanerva , A , Försti , A , Sundquist , K & Hemminki , K 2018 , ' Familial risks of ovarian cancer by age at diagnosis, proband type and histology ' , PLoS One , vol. 13 , no. 10 , 0205000 . https://doi.org/10.1371/journal.pone.0205000

Title: Familial risks of ovarian cancer by age at diagnosis, proband type and histology
Author: Zheng, Guoqiao; Yu, Hongyao; Kanerva, Anna; Försti, Asta; Sundquist, Kristina; Hemminki, Kari
Contributor organization: Akseli Eetu Hemminki / Principal Investigator
Department of Oncology
University of Helsinki
Department of Obstetrics and Gynecology
Date: 2018-10-03
Language: eng
Number of pages: 10
Belongs to series: PLoS One
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0205000
URI: http://hdl.handle.net/10138/253476
Abstract: Ovarian cancer is a heterogeneous disease. Data regarding familial risks for specific proband, age at diagnosis and histology are limited. Such data can assist genetic counseling and help elucidate etiologic differences among various histologic types of ovarian malignancies. By using the Swedish Family-Cancer Database, we calculated relative risks (RRs) for detailed family histories using a two-way comparison, which implied e.g. estimation of RRs for overall ovarian cancer when family history was histology-specific ovarian cancer, and conversely, RRs for histology-specific ovarian cancer when family history was overall ovarian cancer. In families of only mother, only sisters or both mother and sisters diagnosed with ovarian cancer, cancer risks for ovary were 2.40, 2.59 and 10.40, respectively; and were higher for cases diagnosed before the age of 50 years. All histological types showed a familial risk in two-way analyses, except mucinous and sex cord-stromal tumors. RRs for concordant histology were found for serous (2.47), endometrioid (3.59) and mucinous ovarian cancers (6.91). Concordant familial risks were highest for mucinous cancer; for others, some discordant associations, such as endometrioid-undifferentiated (9.27) and serous-undifferentiated (4.80), showed the highest RRs. Familial risks are high for early-onset patients and for those with multiple affected relatives. Sharing of different histological types of ovarian cancer is likely an indication of the complexity of the underlying mechanisms.
3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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