Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype

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Liukkonen , J , Gursoy , U K , Könönen , E , Gürsoy , M , Metso , J , Salminen , A , Kopra , E , Jauhiainen , M , Mäntylä , P , Buhlin , K , Paju , S , Sorsa , T , Nieminen , M S , Lokki , M-L , Sinisalo , J & Pussinen , P J 2018 , ' Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype ' , Innate Immunity , vol. 24 , no. 7 , pp. 439-447 .

Title: Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype
Author: Liukkonen, Joonas; Gursoy, Ulvi K.; Könönen, Eija; Gürsoy, Mervi; Metso, Jari; Salminen, Aino; Kopra, Elisa; Jauhiainen, Matti; Mäntylä, Päivi; Buhlin, Kåre; Paju, Susanna; Sorsa, Timo; Nieminen, Markku S.; Lokki, Marja-Liisa; Sinisalo, Juha; Pussinen, Pirkko J.
Contributor organization: Clinicum
Department of Oral and Maxillofacial Diseases
University of Helsinki
Oral and Maxillofacial Surgery
Timo Sorsa / Principal Investigator
Suu- ja leukakirurgian yksikkö
Department of Medicine
Kardiologian yksikkö
Transplantation Laboratory
HUS Head and Neck Center
HUS Heart and Lung Center
Date: 2018-10
Language: eng
Number of pages: 9
Belongs to series: Innate Immunity
ISSN: 1753-4259
Abstract: Genetic factors play a role in periodontitis. Here we examined whether the risk haplotype of MHC class III region BAT1-NFKBIL1-LTA and lymphotoxin- polymorphisms associate with salivary biomarkers of periodontal disease. A total of 455 individuals with detailed clinical and radiographic periodontal health data were included in the study. A 610K genotyping chip and a Sequenom platform were used in genotyping analyses. Phospholipid transfer protein activity, concentrations of lymphotoxin-, IL-8 and myeloperoxidase, and a cumulative risk score (combining Porphyromonas gingivalis, IL-1 and matrix metalloproteinase-8) were examined in saliva samples. Elevated IL-8 and myeloperoxidase concentrations and cumulative risk scores associated with advanced tooth loss, deepened periodontal pockets and signs of periodontal inflammation. In multiple logistic regression models adjusted for periodontal parameters and risk factors, myeloperoxidase concentration (odds ratio (OR); 1.37, P=0.007) associated with increased odds for having the risk haplotype and lymphotoxin- concentration with its genetic variants rs2857708, rs2009658 and rs2844482. In conclusion, salivary levels of IL-8, myeloperoxidase and cumulative risk scores associate with periodontal inflammation and tissue destruction, while those of myeloperoxidase and lymphotoxin- associate with genetic factors as well.
Subject: Periodontal disease
phospholipid transfer protein
major histocompatibility complex
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion

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