Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype

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Liukkonen , J , Gursoy , U K , Könönen , E , Gürsoy , M , Metso , J , Salminen , A , Kopra , E , Jauhiainen , M , Mäntylä , P , Buhlin , K , Paju , S , Sorsa , T , Nieminen , M S , Lokki , M-L , Sinisalo , J & Pussinen , P J 2018 , ' Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype ' , Innate Immunity , vol. 24 , no. 7 , pp. 439-447 . https://doi.org/10.1177/1753425918796207

Title: Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype
Author: Liukkonen, Joonas; Gursoy, Ulvi K.; Könönen, Eija; Gürsoy, Mervi; Metso, Jari; Salminen, Aino; Kopra, Elisa; Jauhiainen, Matti; Mäntylä, Päivi; Buhlin, Kåre; Paju, Susanna; Sorsa, Timo; Nieminen, Markku S.; Lokki, Marja-Liisa; Sinisalo, Juha; Pussinen, Pirkko J.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Department of Medicine
University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2018-10
Language: eng
Number of pages: 9
Belongs to series: Innate Immunity
ISSN: 1753-4259
URI: http://hdl.handle.net/10138/253478
Abstract: Genetic factors play a role in periodontitis. Here we examined whether the risk haplotype of MHC class III region BAT1-NFKBIL1-LTA and lymphotoxin- polymorphisms associate with salivary biomarkers of periodontal disease. A total of 455 individuals with detailed clinical and radiographic periodontal health data were included in the study. A 610K genotyping chip and a Sequenom platform were used in genotyping analyses. Phospholipid transfer protein activity, concentrations of lymphotoxin-, IL-8 and myeloperoxidase, and a cumulative risk score (combining Porphyromonas gingivalis, IL-1 and matrix metalloproteinase-8) were examined in saliva samples. Elevated IL-8 and myeloperoxidase concentrations and cumulative risk scores associated with advanced tooth loss, deepened periodontal pockets and signs of periodontal inflammation. In multiple logistic regression models adjusted for periodontal parameters and risk factors, myeloperoxidase concentration (odds ratio (OR); 1.37, P=0.007) associated with increased odds for having the risk haplotype and lymphotoxin- concentration with its genetic variants rs2857708, rs2009658 and rs2844482. In conclusion, salivary levels of IL-8, myeloperoxidase and cumulative risk scores associate with periodontal inflammation and tissue destruction, while those of myeloperoxidase and lymphotoxin- associate with genetic factors as well.
Subject: Periodontal disease
lymphotoxin-alpha
phospholipid transfer protein
haplotypes
major histocompatibility complex
interleukin-8
myeloperoxidase
PHOSPHOLIPID-TRANSFER PROTEIN
CORONARY-ARTERY-DISEASE
LYMPHOTOXIN-ALPHA
INFLAMMATORY RESPONSE
GENE POLYMORPHISMS
PLASMA
HOST
PATHOGEN
SUSCEPTIBILITY
POPULATION
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
3121 General medicine, internal medicine and other clinical medicine
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