Postnatal imaging of prenatally detected hydronephrosis-when is voiding cystourethrogram necessary?

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Visuri , S , Kivisaari , R , Jahnukainen , T & Taskinen , S 2018 , ' Postnatal imaging of prenatally detected hydronephrosis-when is voiding cystourethrogram necessary? ' , Pediatric Nephrology , vol. 33 , no. 10 , pp. 1751-1757 .

Title: Postnatal imaging of prenatally detected hydronephrosis-when is voiding cystourethrogram necessary?
Author: Visuri, Sofia; Kivisaari, Reetta; Jahnukainen, Timo; Taskinen, Seppo
Contributor organization: Lastenkirurgian yksikkö
HUS Children and Adolescents
Department of Diagnostics and Therapeutics
Children's Hospital
HUS Medical Imaging Center
University of Helsinki
Faculty of Medicine
Date: 2018-10
Language: eng
Number of pages: 7
Belongs to series: Pediatric Nephrology
ISSN: 0931-041X
Abstract: Objective To evaluate whether grade 4-5 vesicoureteral reflux (VUR) can be predicted from renal ultrasound (RUS) findings and perform voiding cystourethrograms (VCUGs) only on high-risk patients. Methods The RUS and VCUG images of infants with prenatally detected hydronephrosis admitted to our institution between 2003 and 2013 were re-evaluated. The UTI episodes were collected retrospectively from patient journals. Patients with complex urinary tract anomalies were excluded. Results One hundred eighty, 44 female and 136 male, patients (352 renal units (RU)), 23 (30 RU) of them having grade 4-5 VUR, were included. The median age of the patients at the time of the RUS was 1.3 (0.1-3.0) months and the median follow-up time was 2.0 (0.1-11.2) years. In multivariate analysis, a visible ureter (OR 12.72; CI 5.33-32.04, p <0.001) and shorter renal length (OR 2.67; CR 1.504.86, p <0.001) in RUS predicted grade 4-5 VUR while a visible ureter predicted UTIs (OR 5.75; CI 2.59-12.66, p <0.001). A three-grade risk score for high-grade VUR was developed based on the RUS findings and the patients were categorized into low-, intermediate-, and high-risk groups. The incidence of grade 4-5 VUR was 2.9% in the low-risk, 12.2% in the intermediaterisk, and 52.2% in the high-risk group. The sensitivity and specificity for detecting grade 4-5 VUR were 79 and 82%, respectively. Conclusions In patients with antenatally detected hydronephrosis, a visible ureter and reduced renal length in RUS are significant risk factors for high-grade VUR. A RUS-based risk scoring would probably reduce the proportion of unnecessary VCUGs.
Description: Correction: Volume: 33 Issue: 10 Pages: 1805-1805 DOI: 10.1007/s00467-018-3986-3 WOS:000443998400022
Subject: Children
Renal ultrasonography
Vesicoureteral reflux
3123 Gynaecology and paediatrics
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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