Cardiopulmonary effects of vatinoxan in sevoflurane-anaesthetised sheep receiving dexmedetomidine

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Adam , M , Huuskonen , V , Raekallio , M R , Casoni , D , Mykkänen , A K , Lappalainen , A K , Kajula , M , Kallio-Kujala , I J & Vainio , O 2018 , ' Cardiopulmonary effects of vatinoxan in sevoflurane-anaesthetised sheep receiving dexmedetomidine ' , The Veterinary Journal , vol. 238 , pp. 63-69 . https://doi.org/10.1016/j.tvjl.2018.07.007

Title: Cardiopulmonary effects of vatinoxan in sevoflurane-anaesthetised sheep receiving dexmedetomidine
Author: Adam, Magdy; Huuskonen, Vilhelmiina; Raekallio, Marja Riitta; Casoni, Daniela; Mykkänen, Anna Kristina; Lappalainen, Anu Katriina; Kajula, Marena; Kallio-Kujala, Ira Janika; Vainio, Outi
Contributor: University of Helsinki, Departments of Faculty of Veterinary Medicine
University of Helsinki, Marja Raekallio / Principal Investigator
University of Helsinki, University of Bern
University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Outi Vainio / Principal Investigator
Date: 2018
Language: eng
Number of pages: 7
Belongs to series: The Veterinary Journal
ISSN: 1090-0233
URI: http://hdl.handle.net/10138/253494
Abstract: The effects of pre-treatment with vatinoxan (MK-467) on dexmedetomidine-induced cardiopulmonary alterations were investigated in sheep. In a crossover study design with a 20-day washout, seven sheep were anaesthetised with sevoflurane in oxygen and air. The sheep were ventilated with the pressure limited volume-controlled mode and a positive end-expiratory pressure of 5 cmH(2)O. Peak inspiratory pressure (PIP) was set at 25 cmH(2)O. The sheep received either 150 mu g/kg vatinoxan HCl (VAT + DEX) or saline intravenously (IV) 10 min before IV dexmedetomidine HCl (3 mu g/kg, DEX). Cardiopulmonary variables were measured before treatments (baseline), 3 min after vatinoxan or saline, and 5, 15 and 25 min after dexmedetomidine. Computed tomography (CT) of lung parenchyma was performed at baseline, 2 min before dexmedetomidine, and 10, 20 and 30 min after DEX. Bronchoalveolar lavage (BAL) was performed after the last CT scan and shortly before sheep recovered from anaesthesia. After VAT, cardiac output significantly increased from baseline. DEX alone significantly decreased partial arterial oxygen tension, total dynamic compliance and tidal volume, whereas PIP was significantly increased. With VAT + DEX, these changes were minimal. No significant changes were detected in haemodynamics from baseline after DEX. With VAT + DEX, mean arterial pressure and systemic vascular resistance were significantly decreased from baseline, although hypotension was not detected. On CT lung density was significantly increased with DEX as compared to baseline. No visual abnormalities were detected in bronchoscopy and no differences were detected in the BAL fluid after either treatment. The pre-administration of vatinoxan alleviates dexmedetomidine-induced bronchoconstriction, oedema and hypoxaemia in sevoflurane-anaesthetised sheep. (C) 2018 The Author(s). Published by Elsevier Ltd.
Subject: Anaesthesia
Computed tomography
Dexmedetomidine
Sheep
Vatinoxan
HYPOXIC PULMONARY VASOCONSTRICTION
EXTRAVASCULAR LUNG WATER
END-EXPIRATORY PRESSURE
CONSCIOUS SHEEP
INDUCED SEDATION
AIRWAY PRESSURE
ANTAGONIST
L-659,066
XYLAZINE
AGONISTS
413 Veterinary science
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