The Val66Met polymorphism in the BDNF gene is associated with epilepsy in fragile X syndrome

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Louhivuori , V , Arvio , M , Soronen , P , Oksanen , V , Paunio , T & Castren , M L 2009 , ' The Val66Met polymorphism in the BDNF gene is associated with epilepsy in fragile X syndrome ' , Epilepsy Research , vol. 85 , no. 1 , pp. 114-117 . https://doi.org/10.1016/j.eplepsyres.2009.01.005

Title: The Val66Met polymorphism in the BDNF gene is associated with epilepsy in fragile X syndrome
Author: Louhivuori, Verna; Arvio, Maria; Soronen, Pia; Oksanen, Virpi; Paunio, Tiina; Castren, Maija L.
Contributor organization: Department of Physiology
HYKS erva
Clinicum
Department of Psychiatry
Haartman Institute (-2014)
Department of Medical and Clinical Genetics
Institute of Biomedicine (-2014)
NeuroDevDiseaseModelling
Date: 2009
Language: eng
Number of pages: 4
Belongs to series: Epilepsy Research
ISSN: 0920-1211
DOI: https://doi.org/10.1016/j.eplepsyres.2009.01.005
URI: http://hdl.handle.net/10138/253837
Abstract: The Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene may modulate the epilepsy phenotype. We investigated the impact of polymorphisms in the BDNF gene on clinical features in fragile X syndrome (FXS). In our study sample, the Met66 allele associated with epilepsy of finnish FXS men. Abnormalities in BDNF-mediated plasticity are shown in FXS and the present data suggest that the Met66 allele might predispose FXS mates to epilepsy. (C) 2009 Published by Elsevier B.V.The Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene may modulate the epilepsy phenotype. We investigated the impact of polymorphisms in the BDNF gene on clinical features in fragile X syndrome (FXS). In our study sample, the Met66 allele associated with epilepsy of finnish FXS men. Abnormalities in BDNF-mediated plasticity are shown in FXS and the present data suggest that the Met66 allele might predispose FXS mates to epilepsy. (C) 2009 Published by Elsevier B.V.The Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene may modulate the epilepsy phenotype. We investigated the impact of polymorphisms in the BDNF gene on clinical features in fragile X syndrome (FXS). In our study sample, the Met66 allele associated with epilepsy of finnish FXS men. Abnormalities in BDNF-mediated plasticity are shown in FXS and the present data suggest that the Met66 allele might predispose FXS mates to epilepsy. (C) 2009 Published by Elsevier B.V.
Subject: 311 Basic medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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