The Val66Met polymorphism in the BDNF gene is associated with epilepsy in fragile X syndrome

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Louhivuori , V , Arvio , M , Soronen , P , Oksanen , V , Paunio , T & Castren , M L 2009 , ' The Val66Met polymorphism in the BDNF gene is associated with epilepsy in fragile X syndrome ' , Epilepsy Research , vol. 85 , no. 1 , pp. 114-117 . https://doi.org/10.1016/j.eplepsyres.2009.01.005

Title: The Val66Met polymorphism in the BDNF gene is associated with epilepsy in fragile X syndrome
Author: Louhivuori, Verna; Arvio, Maria; Soronen, Pia; Oksanen, Virpi; Paunio, Tiina; Castren, Maija L.
Other contributor: University of Helsinki, Department of Physiology
University of Helsinki, HYKS erva
University of Helsinki, Clinicum
University of Helsinki, Haartman Institute (-2014)







Date: 2009
Language: eng
Number of pages: 4
Belongs to series: Epilepsy Research
ISSN: 0920-1211
DOI: https://doi.org/10.1016/j.eplepsyres.2009.01.005
URI: http://hdl.handle.net/10138/253837
Abstract: The Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene may modulate the epilepsy phenotype. We investigated the impact of polymorphisms in the BDNF gene on clinical features in fragile X syndrome (FXS). In our study sample, the Met66 allele associated with epilepsy of finnish FXS men. Abnormalities in BDNF-mediated plasticity are shown in FXS and the present data suggest that the Met66 allele might predispose FXS mates to epilepsy. (C) 2009 Published by Elsevier B.V.
Subject: 311 Basic medicine
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