A thirteen-year follow-up of respiratory effects of acute exposure to sulfur dioxide

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Piirila , P L , Nordman , H , Korhonen , O & Winblad , I 1996 , ' A thirteen-year follow-up of respiratory effects of acute exposure to sulfur dioxide ' , Scandinavian Journal of Work, Environment & Health , vol. 22 , no. 3 , pp. 191-196 . https://doi.org/10.5271/sjweh.130

Title: A thirteen-year follow-up of respiratory effects of acute exposure to sulfur dioxide
Author: Piirila, Päivi L.; Nordman, Henrik; Korhonen, Olli; Winblad, Ilkka
Contributor: University of Helsinki, Clinicum
University of Helsinki, Finnish Institute of Occupational Health
Date: 1996-06
Language: eng
Number of pages: 6
Belongs to series: Scandinavian Journal of Work, Environment & Health
ISSN: 0355-3140
URI: http://hdl.handle.net/10138/253854
Abstract: Objectives In 1977, nine men were accidentally exposed to sulfur dioxide in an explosion in a pyrite mine. The lung function of seven men was followed after the accident. A four-year follow-up has been published previously. The greatest decrease in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1.0)), and maximal midexpiratory flow (MMEF) was observed one week after the accident, after which all these parameters improved without reaching the preaccident level. Reversible bronchial obstruction was still present in three patients, and a positive reaction In the histamine challenge test was found for four. In the present paper, the lung function follow-up 13 years after the accident is reported for six men. Methods The patients' clinical condition, chest X-ray, spirometry, and histamine challenge test were studied 13 years after the incident. Results Spirometry was normal in one worker, two displayed obstruction, and three had a combined obstructive and restrictive, mainly obstructive, ventilatory impairment. In the histamine challenge test, four patients showed bronchial hyperreactivity, one with a nearly significant reaction. Because of bronchial obstruction one patient could not perform the challenge test. Conclusions This 13-year follow-up showed that acute inflammatory obstruction caused by exposure to sulfur dioxide left, as sequelae, obstructive impairment of ventilatory function and permanent bronchial hyperreactivity. The clinical picture displayed by these patients was named the ''reactive airways dysfunction syndrome'' (RADS) in 1985. Four of the patients also showed symptoms of chronic bronchitis.
Subject: chronic obstructive pulmonary disease
follow-up of lung function
reactive airways dysfunction syndrome
sulfur dioxide exposure
CHRONIC-BRONCHITIS
PERSISTENT ASTHMA
DOGS
RESPONSIVENESS
INFLAMMATION
INHALATION
3142 Public health care science, environmental and occupational health
3121 General medicine, internal medicine and other clinical medicine
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