Electrospun Polyhydroxybutyrate/Poly(epsilon-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications

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Ding , Y , Li , W , Correia , A , Yang , Y , Zheng , K , Liu , D , Schubert , D W , Boccaccini , A R , Santos , H A & Roether , J A 2018 , ' Electrospun Polyhydroxybutyrate/Poly(epsilon-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications ' , ACS Applied Materials & Interfaces , vol. 10 , no. 17 , pp. 14540-14548 . https://doi.org/10.1021/acsami.8b02656

Title: Electrospun Polyhydroxybutyrate/Poly(epsilon-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications
Author: Ding, Yaping; Li, Wei; Correia, Alexandra; Yang, Yuyun; Zheng, Kai; Liu, Dongfei; Schubert, Dirk W.; Boccaccini, Aldo R.; Santos, Helder A.; Roether, Judith A.
Contributor: University of Helsinki, Preclinical Drug Formulation and Analysis group
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Drug Research Program
University of Helsinki, Drug Research Program
Date: 2018-05-02
Language: eng
Number of pages: 9
Belongs to series: ACS Applied Materials & Interfaces
ISSN: 1944-8244
URI: http://hdl.handle.net/10138/255647
Abstract: Electrospun hybrid scaffolds are an effective platform to deliver drugs site specifically for the prevention and treatment of diseases in addition to promote tissue regeneration because of the flexibility to load drugs therein. In the present study, electrospun hybrid scaffolds containing antibiotics were developed to support cellular activities and eliminate potential postoperative inflammation and infection. As a model drug, levofloxacin (LFX) was successfully incorporated into pure polyhydroxybutyrate/poly(epsilon-caprolactone) (PHB/PCL) scaffolds and PHB/PCL/sol-gel-derived silica (SGS) scaffolds. The influence of LFX on the morphology, mechanical performance, chemical structure, drug release profile, and antibacterial effect of the scaffolds was thoroughly and comparatively investigated. MG-63 osteoblast-like cell cultivation on both scaffolds certified that LFX inclusion did not impair the biocompatibility. In addition to the favorable cellular proliferation and differentiation, scaffolds containing both LFX and SGS displayed highly increased mineralization content. Therefore, the present multifunctional hybrid scaffolds are promising in tissue engineering applications.
Subject: 221 Nano-technology
216 Materials engineering
317 Pharmacy
polyhydroxybutyrate
poly(epsilon-caprolactone)
sol-gel silica
hybrid scaffolds
antibacterial
IN-VITRO
POLYMERIC NANOFIBERS
COMPOSITE SCAFFOLDS
CELL BEHAVIOR
DELIVERY
ANTIBIOTICS
STRATEGIES
STIFFNESS
MATRIX
GEL
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