Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions

Show full item record



Permalink

http://hdl.handle.net/10138/255649

Citation

Liu , D , Lipponen , K , Quan , P , Wan , X , Zhan , H , Makilä , E , Salonen , J , Kostiainen , R , Hirvonen , J , Kotiaho , T & Santos , H A 2018 , ' Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions ' , Acs Biomaterials Science & Engineering , vol. 4 , no. 7 , pp. 2308-2313 . https://doi.org/10.1021/acsbiomaterials.8b00343

Title: Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions
Author: Liu, Dongfei; Lipponen, Katriina; Quan, Peng; Wan, Xiaocao; Zhan, Hongbo; Makilä, Ermei; Salonen, Jarno; Kostiainen, Risto; Hirvonen, Jouni; Kotiaho, Tapio; Santos, Helder A.
Contributor: University of Helsinki, Drug Research Program
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Drug Research Program
Date: 2018-07
Language: eng
Number of pages: 6
Belongs to series: Acs Biomaterials Science & Engineering
ISSN: 2373-9878
URI: http://hdl.handle.net/10138/255649
Abstract: By exploiting its porous structure and high loading capacity, porous silicon (PSi) is a promising biomaterial to fabricate protocells and biomimetic reactors. Here, we have evaluated the impact of physicochemical properties of PSi particles [thermally oxidized PSi, TOPSi; annealed TOPSi, AnnTOPSi; (3-aminopropyl) triethoxysilane functionalized thermally carbonized PSi, APTES-TCPSi; and thermally hydrocarbonized PSi, THCPSi] on their surface interactions with different phospholipids. All of the four phospholipids were similarly adsorbed by the surface of PSi particles, except for TOPSi. Among four PSi particles, TOPSi with hydrophilic surface and smaller pore size showed the weakest adsorption toward phosphatidylcholines. By increasing the pore size from roughly 12.5 to 18.0 nm (TOPSi vs AnnTOPSi), the quantity of phosphatidylcholines adsorbed by TOPSi was enhanced to the same level of hydrophilic APTES-TCPSi and hydrophobic THCPSi. The 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) exhibited the highest release ratio of phospholipids from all four PSi particles, and phosphatidylserine (DPPS) showed the lowest release ratio of phospholipids from PSi particles, except for TOPSi, which adsorbed less phospholipids due to the small pore size. There is consistency in the release extent of phospholipids from PSi particles and the isosteric heat of adsorption. Overall, our study demonstrates the importance of pore size and surface chemistry of PSi particles as well as the structure of phospholipids on their interactions. The obtained information can be employed to guide the selection of PSi particles and phospholipids to fabricate highly ordered structures, for example, protocells, or biomimetic reactors.
Subject: 116 Chemical sciences
317 Pharmacy
216 Materials engineering
porous silicon
phospholipids
adsorption
surface chemistry
pore size
DRUG-DELIVERY
ELECTROSTATIC INTERACTION
BILAYER FORMATION
MICROPARTICLES
NANOPARTICLES
RELEASE
COMBINATION
FABRICATION
STRATEGIES
LIPIDOMICS
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
acsbiomaterials.pdf 4.237Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record