Genome-wide identification of geographical segregated genetic markers in Salmonella enterica serovar Typhimurium variant 4,[5],12:i:-

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Palma , F , Manfreda , G , Silva , M , Parisi , A , Barker , D O R , Taboada , E N , Pasquali , F & Rossi , M 2018 , ' Genome-wide identification of geographical segregated genetic markers in Salmonella enterica serovar Typhimurium variant 4,[5],12:i:- ' , Scientific Reports , vol. 8 , 15251 . https://doi.org/10.1038/s41598-018-33266-5

Title: Genome-wide identification of geographical segregated genetic markers in Salmonella enterica serovar Typhimurium variant 4,[5],12:i:-
Author: Palma, Federica; Manfreda, Gerardo; Silva, Mickael; Parisi, Antonio; Barker, Dillon O. R.; Taboada, Eduardo N.; Pasquali, Frederique; Rossi, Mirko
Contributor: University of Helsinki, Mirko Rossi Research Group
Date: 2018-10-15
Language: eng
Number of pages: 12
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/256401
Abstract: Salmonella enterica ser. Typhimurium monophasic variant 4,[5],12:i:- has been associated with food-borne epidemics worldwide and swine appeared to be the main reservoir in most of the countries of isolation. However, the monomorphic nature of this serovar has, so far, hindered identification of the source due to expansion of clonal lineages in multiple hosts and food producing systems. Since geographically structured genetic signals can shape bacterial populations, identification of biogeographical markers in S. 1,4,[5],12:i:- genomes can contribute to improving source attribution. In this study, the phylogeographical structure of 148 geographically and temporally related Italian S. 1,4,[5],12:i:- has been investigated. The Italian isolates belong to a large population of clonal S. Typhimurium/1,4,[5],12:i:- isolates collected worldwide in two decades showing up to 2.5% of allele differences. Phylogenetic reconstruction revealed that isolates from the same geographical origin form highly supported monophyletic groups, suggesting discrete geographical segregation. These monophyletic groups are characterized by the gene content of a large sopE-containing prophage. Within this prophage, genome-wide comparison identified several genes overrepresented in strains of Italian origin. This suggests that certain lineages may be characterized by the acquisition of specific accessory genetic markers useful for improving identification of the source in ongoing epidemics.
Subject: MONOMORPHIC BACTERIAL PATHOGENS
MOLECULAR CHARACTERIZATION
ANTIMICROBIAL RESISTANCE
POPULATION-STRUCTURE
MONOPHASIC VARIANT
VIRULENCE GENES
SPANISH CLONE
SEROTYPE
EVOLUTION
SEQUENCES
1183 Plant biology, microbiology, virology
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