Diabetes, glycaemia, and cognitiona secondary analysis of the Finnish Diabetes Prevention Study

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Lehtisalo , J , Lindstrom , J , Ngandu , T , Kivipelto , M , Ahtiluoto , S , Ilanne-Parikka , P , Keinanen-Kiukaanniemi , S , Eriksson , J G , Uusitupa , M , Tuomilehto , J , Luchsinger , J A & Finnish Diabet Prevention Study DP 2016 , ' Diabetes, glycaemia, and cognitiona secondary analysis of the Finnish Diabetes Prevention Study ' , Diabetes / Metabolism Research and Reviews , vol. 32 , no. 1 , pp. 102-110 . https://doi.org/10.1002/dmrr.2679

Title: Diabetes, glycaemia, and cognitiona secondary analysis of the Finnish Diabetes Prevention Study
Author: Lehtisalo, Jenni; Lindstrom, Jaana; Ngandu, Tiia; Kivipelto, Miia; Ahtiluoto, Satu; Ilanne-Parikka, Pirjo; Keinanen-Kiukaanniemi, Sirkka; Eriksson, Johan G.; Uusitupa, Matti; Tuomilehto, Jaakko; Luchsinger, Jose A.; Finnish Diabet Prevention Study DP
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum



Date: 2016-01
Language: eng
Number of pages: 9
Belongs to series: Diabetes / Metabolism Research and Reviews
ISSN: 1520-7552
DOI: https://doi.org/10.1002/dmrr.2679
URI: http://hdl.handle.net/10138/257912
Abstract: BackgroundType 2 diabetes is linked with cognitive dysfunction and dementia in epidemiological studies, but these observations are limited by lack of data on the exact timing of diabetes onset. We investigated diabetes, dysglycaemia, and cognition in the Finnish Diabetes Prevention Study, in which the timing and duration of diabetes are well documented. MethodsThe Finnish Diabetes Prevention Study comprised middle-aged, overweight participants with impaired glucose tolerance but no diabetes at baseline (n=522), randomized to lifestyle intervention or a control group. After an intervention period (mean duration 4years) and follow-up (additional 9years), cognitive assessment with the CERAD test battery and Trail Making Test A (TMT) was executed twice within a 2-year interval. Of the 364 (70%) participants with cognitive assessments, 171 (47%) had developed diabetes. ResultsCognitive function did not differ between those who developed diabetes and those who did not. Lower mean 2-h glucose at an oral glucose tolerance test (OGTT) and HbA(1C) during the intervention period predicted better performance in the TMT (p=0.012 and 0.024, respectively). Those without diabetes or with short duration of diabetes improved in CERAD total score between the two assessments (p=0.001) whereas those with long duration of diabetes did not (p=0.844). ConclusionsBetter glycemic control among persons with baseline impaired glucose tolerance predicted better cognitive performance 9years later in this secondary analysis of the Finnish Diabetes Prevention Study population. In addition, learning effects in cognitive testing were not evident in people with long diabetes duration. Copyright (c) 2015 John Wiley & Sons, Ltd.
Subject: type 2 diabetes
dysglycaemia
cognition
IMPAIRED GLUCOSE-TOLERANCE
ALZHEIMERS-DISEASE
OLDER-ADULTS
RISK-FACTOR
LIFE-STYLE
DEMENTIA
DECLINE
WOMEN
MELLITUS
DYSFUNCTION
3142 Public health care science, environmental and occupational health
3121 General medicine, internal medicine and other clinical medicine
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