Diabetes, glycaemia, and cognitiona secondary analysis of the Finnish Diabetes Prevention Study

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dc.contributor.author Lehtisalo, Jenni
dc.contributor.author Lindstrom, Jaana
dc.contributor.author Ngandu, Tiia
dc.contributor.author Kivipelto, Miia
dc.contributor.author Ahtiluoto, Satu
dc.contributor.author Ilanne-Parikka, Pirjo
dc.contributor.author Keinanen-Kiukaanniemi, Sirkka
dc.contributor.author Eriksson, Johan G.
dc.contributor.author Uusitupa, Matti
dc.contributor.author Tuomilehto, Jaakko
dc.contributor.author Luchsinger, Jose A.
dc.contributor.author Finnish Diabet Prevention Study DP
dc.date.accessioned 2018-11-06T22:14:25Z
dc.date.available 2018-11-06T22:14:25Z
dc.date.issued 2016-01
dc.identifier.citation Lehtisalo , J , Lindstrom , J , Ngandu , T , Kivipelto , M , Ahtiluoto , S , Ilanne-Parikka , P , Keinanen-Kiukaanniemi , S , Eriksson , J G , Uusitupa , M , Tuomilehto , J , Luchsinger , J A & Finnish Diabet Prevention Study DP 2016 , ' Diabetes, glycaemia, and cognitiona secondary analysis of the Finnish Diabetes Prevention Study ' , Diabetes / Metabolism Research and Reviews , vol. 32 , no. 1 , pp. 102-110 . https://doi.org/10.1002/dmrr.2679
dc.identifier.other PURE: 59533667
dc.identifier.other PURE UUID: 30ad008a-70fa-42e2-8a26-bf3d7ae8edda
dc.identifier.other WOS: 000368012000012
dc.identifier.other Scopus: 84953836387
dc.identifier.uri http://hdl.handle.net/10138/257912
dc.description.abstract BackgroundType 2 diabetes is linked with cognitive dysfunction and dementia in epidemiological studies, but these observations are limited by lack of data on the exact timing of diabetes onset. We investigated diabetes, dysglycaemia, and cognition in the Finnish Diabetes Prevention Study, in which the timing and duration of diabetes are well documented. MethodsThe Finnish Diabetes Prevention Study comprised middle-aged, overweight participants with impaired glucose tolerance but no diabetes at baseline (n=522), randomized to lifestyle intervention or a control group. After an intervention period (mean duration 4years) and follow-up (additional 9years), cognitive assessment with the CERAD test battery and Trail Making Test A (TMT) was executed twice within a 2-year interval. Of the 364 (70%) participants with cognitive assessments, 171 (47%) had developed diabetes. ResultsCognitive function did not differ between those who developed diabetes and those who did not. Lower mean 2-h glucose at an oral glucose tolerance test (OGTT) and HbA(1C) during the intervention period predicted better performance in the TMT (p=0.012 and 0.024, respectively). Those without diabetes or with short duration of diabetes improved in CERAD total score between the two assessments (p=0.001) whereas those with long duration of diabetes did not (p=0.844). ConclusionsBetter glycemic control among persons with baseline impaired glucose tolerance predicted better cognitive performance 9years later in this secondary analysis of the Finnish Diabetes Prevention Study population. In addition, learning effects in cognitive testing were not evident in people with long diabetes duration. Copyright (c) 2015 John Wiley & Sons, Ltd. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Diabetes / Metabolism Research and Reviews
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject type 2 diabetes
dc.subject dysglycaemia
dc.subject cognition
dc.subject IMPAIRED GLUCOSE-TOLERANCE
dc.subject ALZHEIMERS-DISEASE
dc.subject OLDER-ADULTS
dc.subject RISK-FACTOR
dc.subject LIFE-STYLE
dc.subject DEMENTIA
dc.subject DECLINE
dc.subject WOMEN
dc.subject MELLITUS
dc.subject DYSFUNCTION
dc.subject 3142 Public health care science, environmental and occupational health
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Diabetes, glycaemia, and cognitiona secondary analysis of the Finnish Diabetes Prevention Study en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Public Health
dc.contributor.organization Johan Eriksson / Principal Investigator
dc.contributor.organization Department of General Practice and Primary Health Care
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1002/dmrr.2679
dc.relation.issn 1520-7552
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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