Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations

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Barrios , C , Zierer , J , Würtz , P , Haller , T , Metspalu , A , Gieger , C , Thorand , B , Meisinger , C , Waldenberger , M , Raitakari , O , Lehtimäki , T , Otero , S , Rodriguez , E , Pedro-Botet , J , Kähönen , M , Ala-Korpela , M , Kastenmüller , G , Spector , T D , Pascual , J & Menni , C 2018 , ' Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations ' Scientific Reports , vol. 8 , 15249 . https://doi.org/10.1038/s41598-018-33507-7

Title: Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations
Author: Barrios, Clara; Zierer, Jonas; Würtz, Peter; Haller, Toomas; Metspalu, Andres; Gieger, Christian; Thorand, Barbara; Meisinger, Christa; Waldenberger, Melanie; Raitakari, Olli; Lehtimäki, Terho; Otero, Sol; Rodriguez, Eva; Pedro-Botet, Juan; Kähönen, Mika; Ala-Korpela, Mika; Kastenmüller, Gabi; Spector, Tim D.; Pascual, Julio; Menni, Cristina
Contributor: University of Helsinki, Research Programs Unit
Date: 2018-10-15
Number of pages: 11
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/259030
Abstract: Using targeted NMR spectroscopy of 227 fasting serum metabolic traits, we searched for novel metabolic signatures of renal function in 926 type 2 diabetics (T2D) and 4838 non-diabetic individuals from four independent cohorts. We furthermore investigated longitudinal changes of metabolic measures and renal function and associations with other T2D microvascular complications. 142 traits correlated with glomerular filtration rate (eGFR) after adjusting for confounders and multiple testing: 59 in diabetics, 109 in non-diabetics with 26 overlapping. The amino acids glycine and phenylalanine and the energy metabolites citrate and glycerol were negatively associated with eGFR in all the cohorts, while alanine, valine and pyruvate depicted opposite association in diabetics (positive) and nondiabetics (negative). Moreover, in all cohorts, the triglyceride content of different lipoprotein subclasses showed a negative association with eGFR, while cholesterol, cholesterol esters (CE), and phospholipids in HDL were associated with better renal function. In contrast, phospholipids and CEs in LDL showed positive associations with eGFR only in T2D, while phospholipid content in HDL was positively associated with eGFR both cross-sectionally and longitudinally only in non-diabetics. In conclusion, we provide a wide list of kidney function-associated metabolic traits and identified novel metabolic differences between diabetic and non-diabetic kidney disease.
Subject: CHRONIC KIDNEY-DISEASE
CHOLESTEROL EFFLUX CAPACITY
MAGNETIC-RESONANCE METABOLOMICS
HDL PHOSPHOLIPID CONTENT
CARDIOVASCULAR EVENTS
COHORT PROFILE
AMINO-ACIDS
IN-VIVO
PHENYLALANINE
MELLITUS
3111 Biomedicine
3121 Internal medicine
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