Early life colonization of the human gut : microbes matter everywhere

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http://hdl.handle.net/10138/260554

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Korpela , K & de Vos , W M 2018 , ' Early life colonization of the human gut : microbes matter everywhere ' , Current Opinion in Microbiology , vol. 44 , pp. 70-78 . https://doi.org/10.1016/j.mib.2018.06.003

Title: Early life colonization of the human gut : microbes matter everywhere
Author: Korpela, Katri; de Vos, Willem M.
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Medicum
Date: 2018-08
Language: eng
Number of pages: 9
Belongs to series: Current Opinion in Microbiology
ISSN: 1369-5274
URI: http://hdl.handle.net/10138/260554
Abstract: Microbes colonising the infant intestine, especially bacteria, are considered important for metabolic and immunological programming in early life, potentially affecting the susceptibility of the host to disease. We combined published data to provide a global view of microbiota development in early life. The results support the concept that the microbiota develops with age in an orchestrated manner, showing common patterns across populations. Furthermore, infants are colonised at birth by specific, selected maternal faecal bacteria and likely their bacteriophages. Therefore, infants are adapted to receiving specific bacterial signals, partly derived from the maternal microbiota, at successive immunological time windows during early development. Birth by caesarean section compromises the initial vertical transmission of microbes whereas antibiotic use shifts the microbiota away from the normal developmental pattern. These disruptions alter the microbial signals that the host receives, potentially affecting child development.
Subject: INTESTINAL MICROBIOTA
MILK OLIGOSACCHARIDES
6-WEEK-OLD INFANTS
YOUNG-CHILDREN
DELIVERY MODE
1ST YEAR
DYNAMICS
REVEALS
METAGENOMICS
TRANSMISSION
3111 Biomedicine
1183 Plant biology, microbiology, virology
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