Lung function in adults born preterm

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http://hdl.handle.net/10138/260955

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Näsänen-Gilmore , P , Sipola-Leppänen , M , Tikanmäki , M , Matinolli , H-M , Eriksson , J G , Järvelin , M-R , Vääräsmäki , M , Hovi , P & Kajantie , E 2018 , ' Lung function in adults born preterm ' , PLoS One , vol. 13 , no. 10 , 0205979 . https://doi.org/10.1371/journal.pone.0205979

Title: Lung function in adults born preterm
Author: Näsänen-Gilmore, Pieta; Sipola-Leppänen, Marika; Tikanmäki, Marjaana; Matinolli, Hanna-Maria; Eriksson, Johan G.; Järvelin, Marjo-Riitta; Vääräsmäki, Marja; Hovi, Petteri; Kajantie, Eero
Contributor: University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Clinicum
University of Helsinki, Lastentautien yksikkö
Date: 2018-10-19
Language: eng
Number of pages: 15
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/260955
Abstract: Very preterm birth, before the gestational age (GA) of 32 weeks, increases the risk of obstructed airflow in adulthood. We examined whether all preterm births (GA= 37 weeks). Preterm birth was associated with poorer lung function. Mean differences between individuals born early preterm versus full-term were -0.23 standard deviation (SD) (95% confidence interval (CI): -0.40, -0.05)) for forced vital capacity z-score (zFVC), -0.44 SD (95% CI -0.64, -0.25) for forced expiratory volume z-score (zFEV1), and -0.29 SD (95% CI -0.47, -0.10) for zFEV1/FVC. For late preterm, mean differences with full-term controls were -0.02 SD (95% CI -0.17, 0.13), -0.12 SD (95% CI -0.29, 0.04) and -0.13 SD (95% CI -0.29, 0.02) for zFVC, zFEV1, and zFEV1/FVC, respectively. Examination of finer GA subgroups suggested an inverse non-linear association between lung function and GA, with the greatest impact on zFEV1 for those born extremely preterm. The subgroup means were GA= 37weeks): 0.02 SD. Corresponding means for zFEV1/FVC were -1.79, -0.44, -0.47, -0.48, -0.29, and -0.02. Adjustment for maternal pregnancy conditions and socioeconomic and lifestyle factors had no major impact on the relationship. Preterm birth is associated with airflow limitation in adult life. The association appears to be attributable predominantly to those born most immature, with only a modest decrease among those born preterm at later gestational ages.
Subject: OBSTRUCTIVE PULMONARY-DISEASE
LOW-BIRTH-WEIGHT
BRONCHOPULMONARY DYSPLASIA
SCHOOL-AGE
CHILDHOOD ASTHMA
MATERNAL SMOKING
CHILDREN BORN
PREGNANCY
INFANTS
ADOLESCENTS
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
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