Decreases in TGF-1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer

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http://hdl.handle.net/10138/260956

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Aula , H , Skyttä , T , Tuohinen , S , Luukkaala , T , Hämäläinen , M , Virtanen , V , Raatikainen , P , Moilanen , E & Kellokumpu-Lehtinen , P-L 2018 , ' Decreases in TGF-1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer ' , Radiation oncology , vol. 13 , 201 . https://doi.org/10.1186/s13014-018-1150-7

Title: Decreases in TGF-1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer
Author: Aula, Hanna; Skyttä, Tanja; Tuohinen, Suvi; Luukkaala, Tiina; Hämäläinen, Mari; Virtanen, Vesa; Raatikainen, Pekka; Moilanen, Eeva; Kellokumpu-Lehtinen, Pirkko-Liisa
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2018-10-19
Number of pages: 10
Belongs to series: Radiation oncology
ISSN: 1748-717X
URI: http://hdl.handle.net/10138/260956
Abstract: BackgroundRadiation-induced heart disease is mainly caused by activation of the fibrotic process. Transforming growth factor-beta 1 (TGF-1) and platelet-derived growth factor (PDGF) are pro-fibrotic mediators. The aim of our study was to evaluate the behavior of TGF-1 and PDGF during adjuvant radiotherapy (RT) for breast cancer and the association of these cytokines with echocardiographic changes.MethodsOur study included 73 women with early-stage breast cancer or ductal carcinoma in situ (DCIS) receiving post-operative RT but not chemotherapy. TGF-1 and PDGF levels in serum samples taken before and on the last day of RT were measured by an enzyme-linked immunosorbent assay. Echocardiography was also performed at same time points. Patients were grouped according to a15% worsening in tricuspid annular plane systolic excursion (TAPSE) and pericardium calibrated integrated backscatter (cIBS).ResultsIn all patients, the median TGF-1 decreased from 25.0 (IQR 21.1-30.3) ng/ml to 23.6 (IQR 19.6-26.8) ng/ml (p=0.003), and the median PDGF decreased from 18.0 (IQR 13.7-22.7) ng/ml to 15.6 (IQR 12.7-19.5) ng/ml (p
Subject: Cardiotoxicity
Breast cancer
Radiotherapy
Transforming growth factor beta-1
Platelet-derived growth factor
Echocardiography
GROWTH-FACTOR-BETA
CELL LUNG-CANCER
MYOCARDIAL-INFARCTION
EUROPEAN ASSOCIATION
INHIBITION INCREASES
RADIATION FIBROSIS
DIASTOLIC FUNCTION
AMERICAN SOCIETY
SERUM-LEVELS
IN-VITRO
3122 Cancers
3126 Surgery, anesthesiology, intensive care, radiology
3121 Internal medicine
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