FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

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Minh Binh Nguyen , Cohen , I , Kumar , V , Xu , Z , Bar , C , Dauber-Decker , K L , Tsai , P-C , Marangoni , P , Klein , O D , Hsu , Y-C , Chen , T , Mikkola , M L & Ezhkova , E 2018 , ' FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells ' , Nature Communications , vol. 9 , 2333 . https://doi.org/10.1038/s41467-018-04399-y

Title: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
Author: Minh Binh Nguyen,; Cohen, Idan; Kumar, Vinod; Xu, Zijian; Bar, Carmit; Dauber-Decker, Katherine L.; Tsai, Pai-Chi; Marangoni, Pauline; Klein, Ophir D.; Hsu, Ya-Chieh; Chen, Ting; Mikkola, Marja L.; Ezhkova, Elena
Other contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology

Date: 2018-06-13
Language: eng
Number of pages: 10
Belongs to series: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-018-04399-y
URI: http://hdl.handle.net/10138/260966
Abstract: Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In murine dorsal skin, Merkel cells are located in touch domes and found in the epidermis around primary hairs. While it has been shown that Merkel cells are skin epithelial cells, the progenitor cell population that gives rise to these cells is unknown. Here, we show that during embryogenesis, SOX9-positive (+) cells inside hair follicles, which were previously known to give rise to hair follicle stem cells (HFSCs) and cells of the hair follicle lineage, can also give rise to Merkel Cells. Interestingly, while SOX9 is critical for HFSC specification, it is dispensable for Merkel cell formation. Conversely, FGFR2 is required for Merkel cell formation but is dispensable for HFSCs. Together, our studies uncover SOX9(+) cells as precursors of Merkel cells and show the requirement for FGFR2-mediated epithelial signalling in Merkel cell specification.
Subject: TRANSIT-AMPLIFYING CELLS
FOLLICLE STEM-CELLS
TISSUE REGENERATION
SONIC HEDGEHOG
SKIN
TOUCH
DIFFERENTIATION
MORPHOGENESIS
LINEAGE
GROWTH
1182 Biochemistry, cell and molecular biology
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