Effect of Exercise on Drug-Related Falls Among Persons with Alzheimer's Disease : A Secondary Analysis of the FINALEX Study

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dc.contributor.author Perttilä, Niko M.
dc.contributor.author Öhman, Hanna
dc.contributor.author Strandberg, Timo E.
dc.contributor.author Kautiainen, Hannu
dc.contributor.author Raivio, Minna
dc.contributor.author Laakkonen, Marja-Liisa
dc.contributor.author Savikko, Niina
dc.contributor.author Tilvis, Reijo S.
dc.contributor.author Pitkälä, Kaisu H.
dc.date.accessioned 2018-11-15T07:34:01Z
dc.date.available 2018-11-15T07:34:01Z
dc.date.issued 2018-11
dc.identifier.citation Perttilä , N M , Öhman , H , Strandberg , T E , Kautiainen , H , Raivio , M , Laakkonen , M-L , Savikko , N , Tilvis , R S & Pitkälä , K H 2018 , ' Effect of Exercise on Drug-Related Falls Among Persons with Alzheimer's Disease : A Secondary Analysis of the FINALEX Study ' , Drugs & Aging , vol. 35 , no. 11 , pp. 1017-1023 . https://doi.org/10.1007/s40266-018-0594-7
dc.identifier.other PURE: 118488230
dc.identifier.other PURE UUID: 06fedd20-3b92-4bde-a4d2-ea82366c4dbe
dc.identifier.other WOS: 000448963400007
dc.identifier.other Scopus: 85055313191
dc.identifier.other ORCID: /0000-0001-9659-6985/work/50862970
dc.identifier.other ORCID: /0000-0001-6299-925X/work/50874208
dc.identifier.uri http://hdl.handle.net/10138/262134
dc.description.abstract Introduction No study has investigated how exercise modifies the effect of fall-related drugs (FRDs) on falls among people with Alzheimer's disease (AD). Objective The aim of this study was to investigate how exercise intervention and FRDs interact with fall risk among patients with AD. Methods In the FINALEX trial, community-dwelling persons with AD received either home-based or group-based exercise twice weekly for 1 year (n = 129); the control group received normal care (n = 65). The number of falls was based on spouses' fall diaries. We examined the incidence rate ratios (IRRs) for falls among both non-users and users of various FRDs (antihypertensives, psychotropics, drugs with anticholinergic properties [DAPs]) in both control and combined intervention groups. Results Between the intervention and control groups, there was no difference in the number of falls among those without antihypertensives or psychotropics. In the intervention group taking antihypertensives, the IRR was 0.5 falls/person-year (95% confidence interval [CI] 0.4-0.6), while in the control group, the IRR was 1.5 falls/person-year (95% CI 1.2-1.8) [p <0.001 for group, p = 0.067 for medication, p <0.001 for interaction]. Among patients using psychotropics, the intervention group had an IRR of 0.7 falls/person-year (95% CI 0.6-0.9), while the control group had an IRR of 2.0 falls/person-year (95% CI 1.6-2.5) [p <0.001 for group, p = 0.071 for medication, p <0.001 for interaction]. There was a significant difference in falls between the intervention and control groups not using DAPs (0.6, 95% CI 0.5-0.7; 1.2, 95% CI 1.0-1.4), and between the intervention and control groups using DAPs (1.1, 95% CI 0.8-1.3; 1.5, 95% CI 1.0-2.1) [p <0.001 for group, p = 0.014 for medication, p = 0.97 for interaction]. Conclusion Exercise has the potential to decrease the risk for falls among people with AD using antihypertensives and psychotropics. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Drugs & Aging
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject RANDOMIZED-CONTROLLED-TRIAL
dc.subject RISK-FACTORS
dc.subject NURSING-HOME
dc.subject OLDER-ADULTS
dc.subject COGNITIVE IMPAIRMENT
dc.subject ELDERLY PERSONS
dc.subject DEMENTIA
dc.subject COMMUNITY
dc.subject METAANALYSIS
dc.subject ASSOCIATION
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 316 Nursing
dc.subject 317 Pharmacy
dc.title Effect of Exercise on Drug-Related Falls Among Persons with Alzheimer's Disease : A Secondary Analysis of the FINALEX Study en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of General Practice and Primary Health Care
dc.contributor.organization University of Helsinki
dc.contributor.organization Timo Strandberg / Principal Investigator
dc.contributor.organization Department of Medicine
dc.contributor.organization HUS Internal Medicine and Rehabilitation
dc.contributor.organization Teachers' Academy
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1007/s40266-018-0594-7
dc.relation.issn 1170-229X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion
dc.identifier.url https://rdcu.be/bbqmR

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