An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

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http://hdl.handle.net/10138/262145

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Liu , X , Zhang , H , Cheng , R , Gu , Y , Yin , Y , Sun , Z , Pan , G , Deng , Z , Yang , H , Deng , L , Cui , W , Almeida Santos , H & Shi , Q 2018 , ' An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration ' , Materials Horizons , vol. 5 , no. 6 , pp. 1082-1091 . https://doi.org/10.1039/C8MH00704G

Title: An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration
Author: Liu, Xingzhi; Zhang, Hongbo; Cheng, Ruoyu; Gu, Yanzheng; Yin, Yin; Sun, Zhiyong; Pan, Guoqing; Deng, Zhongbin; Yang, Huilin; Deng, Lianfu; Cui, Wenguo; Almeida Santos, Helder; Shi, Qin
Contributor: University of Helsinki, Drug Research Program
Date: 2018-11-01
Language: eng
Number of pages: 10
Belongs to series: Materials Horizons
ISSN: 2051-6347
URI: http://hdl.handle.net/10138/262145
Abstract: Antibody-based cancer immune therapy has attracted lots of research interest in recent years; however, it is greatly limited by the easy distribution and burst release of antibodies. In addition, after the clearance of the tissue, healthy tissue regeneration is another challenge for cancer treatment. Herein, we have developed a specific immunological tissue engineering scaffold using the agonistic mouse anti-human CD40 antibody (CD40mAb) incorporated into poly(l-lactide) (PLLA) electrospun fibers through the dopamine (PDA) motif (PLLA-PDA-CD40mAb). CD40mAb is successfully incorporated onto the surface of the electrospun fibrous scaffold, which is proved by immunofluorescence staining, and the PLLA-PDA-CD40mAb scaffold has an anti-tumor effect by locally releasing CD40mAb. Therefore, this immunological electrospun scaffold has very good potential to be developed as a powerful tool for localized tumor treatment, and this is the first to be reported in this area.
Subject: 1182 Biochemistry, cell and molecular biology
317 Pharmacy
ANTIBODY-BASED TREATMENT
EXPRESSING CD40 LIGAND
MONOCLONAL-ANTIBODY
DENDRITIC CELLS
CANCER-PATIENTS
BREAST-CANCER
PLLA SCAFFOLD
ACTIVATION
PROLIFERATION
LYMPHOCYTES
ANTIBODY-BASED TREATMENT
EXPRESSING CD40 LIGAND
MONOCLONAL-ANTIBODY
DENDRITIC CELLS
CANCER-PATIENTS
BREAST-CANCER
PLLA SCAFFOLD
ACTIVATION
PROLIFERATION
LYMPHOCYTES
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