Men and women respond differently to rapid weight loss : Metabolic outcomes of a multi-centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW)

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Christensen , P , Larsen , T M , Westerterp-Plantenga , M , Macdonald , I , Martinez , J A , Handjiev , S , Poppitt , S , Hansen , S , Ritz , C , Astrup , A , Pastor-Sanz , L , Sando-Pedersen , F , Pietiläinen , K H , Sundvall , J , Drummen , M , Taylor , M A , Navas-Carretero , S , Handjieva-Darlenska , T , Brodie , S , Silvestre , M P , Huttunen-Lenz , M , Brand-Miller , J , Fogelholm , M & Raben , A 2018 , ' Men and women respond differently to rapid weight loss : Metabolic outcomes of a multi-centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW) ' , Diabetes, obesity and metabolism , vol. 20 , no. 12 , pp. 2840-2851 . https://doi.org/10.1111/dom.13466

Title: Men and women respond differently to rapid weight loss : Metabolic outcomes of a multi-centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW)
Author: Christensen, Pia; Larsen, Thomas Meinert; Westerterp-Plantenga, Margriet; Macdonald, Ian; Martinez, J. Alfredo; Handjiev, Svetoslav; Poppitt, Sally; Hansen, Sylvia; Ritz, Christian; Astrup, Arne; Pastor-Sanz, Laura; Sando-Pedersen, Finn; Pietiläinen, Kirsi H.; Sundvall, Jouko; Drummen, Mathijs; Taylor, Moira A.; Navas-Carretero, Santiago; Handjieva-Darlenska, Teodora; Brodie, Shannon; Silvestre, Marta P.; Huttunen-Lenz, Maija; Brand-Miller, Jennie; Fogelholm, Mikael; Raben, Anne
Contributor: University of Helsinki, Department of Medicine
University of Helsinki, Doctoral Programme in Food Chain and Health
Date: 2018-12
Language: eng
Number of pages: 12
Belongs to series: Diabetes, obesity and metabolism
ISSN: 1462-8902
URI: http://hdl.handle.net/10138/265094
Abstract: Aims Materials and methods The PREVIEW lifestyle intervention study ( Identifier: NCT01777893) is, to date, the largest, multinational study concerning prevention of type-2 diabetes. We hypothesized that the initial, fixed low-energy diet (LED) would induce different metabolic outcomes in men vs women. All participants followed a LED (3.4 MJ/810 kcal/daily) for 8 weeks (Cambridge Weight Plan). Participants were recruited from 8 sites in Europe, Australia and New Zealand. Those eligible for inclusion were overweight (BMI >= 25 kg/m(2)) individuals with pre-diabetes according to ADA-criteria. Outcomes of interest included changes in insulin resistance, fat mass (FM), fat-free mass (FFM) and metabolic syndrome Z-score. Results Conclusions In total, 2224 individuals (1504 women, 720 men) attended the baseline visit and 2020 (90.8%) completed the follow-up visit. Following the LED, weight loss was 16% greater in men than in women (11.8% vs 10.3%, respectively) but improvements in insulin resistance were similar. HOMA-IR decreased by 1.50 +/- 0.15 in men and by 1.35 +/- 0.15 in women (ns). After adjusting for differences in weight loss, men had larger reductions in metabolic syndrome Z-score, C-peptide, FM and heart rate, while women had larger reductions in HDL cholesterol, FFM, hip circumference and pulse pressure. Following the LED, 35% of participants of both genders had reverted to normo-glycaemia. An 8-week LED induced different effects in women than in men. These findings are clinically important and suggest gender-specific changes after weight loss. It is important to investigate whether the greater decreases in FFM, hip circumference and HDL cholesterol in women after rapid weight loss compromise weight loss maintenance and future cardiovascular health.
Subject: dietary intervention
obesity
prevention
weight loss
pre-diabetes
LOW-CALORIE DIET
GENDER-DIFFERENCES
BARIATRIC SURGERY
PHYSICAL-ACTIVITY
BODY-COMPOSITION
FAT
MAINTENANCE
MANAGEMENT
REDUCTION
EXERCISE
3121 General medicine, internal medicine and other clinical medicine
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