Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients

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Jouhi , L , Mohamed , H , Makitie , A , Remes , S M , Haglund , C , Atula , T & Hagstrom , J 2017 , ' Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients ' , Cancer Immunology, Immunotherapy , vol. 66 , no. 12 , pp. 1619-1629 . https://doi.org/10.1007/s00262-017-2054-3

Title: Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients
Author: Jouhi, Lauri; Mohamed, Hesham; Makitie, Antti; Remes, Satu Maria; Haglund, Caj; Atula, Timo; Hagstrom, Jaana
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Pathology
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017-12
Language: eng
Number of pages: 11
Belongs to series: Cancer Immunology, Immunotherapy
ISSN: 0340-7004
URI: http://hdl.handle.net/10138/267582
Abstract: A large subset of oropharyngeal squamous cell carcinomas (OPSCCs) is associated with HPV infection and has better outcome than non-viral-related tumors. Various malignancies also carry a role for TLRs, key activators of inflammation and innate immunity. We examined the expression of TLRs in OPSCC, and their association with HPV status and treatment outcome. TLR 5, 7, 9, and p16 were studied by immunohistochemistry and HPV status was detected with in situ hybridization in 202 tumors of consecutively treated OPSCC patients using tissue microarray method. The relations between TLR expression and HPV status, p16 expression, clinicopathological factors, and survival were analyzed. TLR 5, 7, and 9 expression patterns differed between HPV-positive and -negative tumors, and they were statistically significantly associated with history of smoking, heavy drinking, tumor site, grade, size (T), metastasis (N), and stage. Moreover, in HPV-positive tumors the expression of TLR 5 and 7 correlated with tumor recurrence. After adjustment, among HPV-positive OPSCC patients, high TLR 5 and low TLR 7 expression were associated with poor disease-specific survival. Our results indicate that TLR 5 and 7 may have a role in the prognostication of HPV-positive OPSCC, however, further studies are needed to clarify the comprehensive role of these TLRs in OPSCC.
Subject: Head and neck cancer
Oropharynx
Carcinoma
Human papillomavirus
Toll-like receptor
Survival
HUMAN-PAPILLOMAVIRUS
LUNG-CANCER
SURVIVAL
EPIDEMIC
AGONIST
TONGUE
ADENOCARCINOMA
PROGRESSION
ACTIVATION
INFECTION
3122 Cancers
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