Tumor-infiltrating lymphocytes associate with outcome in nonendemic nasopharyngeal carcinoma : a multicenter study

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Almangush , A , Ruuskanen , M , Hagstrom , J , Hirvikoski , P , Tommola , S , Kosma , V-M , Nieminen , P , Makitie , A & Leivo , L 2018 , ' Tumor-infiltrating lymphocytes associate with outcome in nonendemic nasopharyngeal carcinoma : a multicenter study ' , Human Pathology , vol. 81 , pp. 211-219 . https://doi.org/10.1016/j.humpath.2018.07.009

Title: Tumor-infiltrating lymphocytes associate with outcome in nonendemic nasopharyngeal carcinoma : a multicenter study
Author: Almangush, Alhadi; Ruuskanen, Miia; Hagstrom, Jaana; Hirvikoski, Pasi; Tommola, Satu; Kosma, Veli-Matti; Nieminen, Pentti; Makitie, Antti; Leivo, Limo
Contributor: University of Helsinki, Department of Pathology
University of Helsinki, Medicum
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
Date: 2018-11
Language: eng
Number of pages: 9
Belongs to series: Human Pathology
ISSN: 0046-8177
URI: http://hdl.handle.net/10138/273455
Abstract: The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been studied recently in many cancers. For the first time in a nonendemic region, we have evaluated the prognostic value of TILs in a whole population based nationwide cohort of nasopharyngeal carcinoma (NPC) in Finland. A total of 115 cases from Finnish hospitals were included. TILs were analyzed using hematoxylin and eosin stained slides according to the criteria of the International Immuno-Oncology Biomarker Working Group. TILs were evaluated separately in stromal and tumor compartments. The log-rank test and univariable and multivariable analyses were used to compare survival in patients with tumors with low and high TILs. A significant positive correlation was observed between the occurrence of intratumoral and stromal TILs (P <.001). In multivariable analysis, NPC cases with low intratumoral TILs had poor overall survival with a hazard ratio (HR) of 2.55 and 95% confidence interval (95% CI) of 1.60 to 4.05 (P <.001). Cases with low intratumoral TILs also had poor disease-specific survival (HR, 2.02; 95% CI, 1.16-3.52; P = .015). Keratinized tumors with low intratumoral TILs were associated with an even poorer overall survival (HR, 3.94; 95% CI, 2.17-7.15; P <.001) and a poor disease-specific survival (HR, 2.97; 95% CI, 1.46-6.05; P = .009). Our study demonstrates that the evaluation of TILs is simple and can be assessed routinely in NPC. (C) 2018 Elsevier Inc. All rights reserved.
Subject: Nasopharyngeal carcinoma (NPC)
Tumor-infiltrating lymphocytes (TILs)
Prognosis
Marker
Survival
PROGNOSTIC-SIGNIFICANCE
BREAST-CANCER
INTEROBSERVER AGREEMENT
TILS
PATHOLOGISTS
3111 Biomedicine
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