Effect of blood glucose level on standardized uptake value (SUV) in F-18- FDG PET-scan : a systematic review and meta-analysis of 20,807 individual SUV measurements

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Eskian , M , Alavi , A , Khorasanizadeh , M , Viglianti , B L , Jacobsson , H , Barwick , T D , Meysamie , A , Yi , S K , Iwano , S , Bybel , B , Caobelli , F , Lococo , F , Gea , J , Sancho-Munoz , A , Schildt , J , Tatci , E , Lapa , C , Keramida , G , Peters , M , Boktor , R R , John , J , Pitman , A G , Mazurek , T & Rezaei , N 2019 , ' Effect of blood glucose level on standardized uptake value (SUV) in F-18- FDG PET-scan : a systematic review and meta-analysis of 20,807 individual SUV measurements ' , European Journal of Nuclear Medicine and Molecular Imaging , vol. 46 , no. 1 , pp. 224-237 . https://doi.org/10.1007/s00259-018-4194-x

Title: Effect of blood glucose level on standardized uptake value (SUV) in F-18- FDG PET-scan : a systematic review and meta-analysis of 20,807 individual SUV measurements
Author: Eskian, Mahsa; Alavi, Abass; Khorasanizadeh, MirHojjat; Viglianti, Benjamin L.; Jacobsson, Hans; Barwick, Tara D.; Meysamie, Alipasha; Yi, Sun K.; Iwano, Shingo; Bybel, Bohdan; Caobelli, Federico; Lococo, Filippo; Gea, Joaquim; Sancho-Munoz, Antonio; Schildt, Jukka; Tatci, Ebru; Lapa, Constantin; Keramida, Georgia; Peters, Michael; Boktor, Raef R.; John, Joemon; Pitman, Alexander G.; Mazurek, Tomasz; Rezaei, Nima
Other contributor: University of Helsinki, Department of Diagnostics and Therapeutics


Date: 2019-01
Language: eng
Number of pages: 14
Belongs to series: European Journal of Nuclear Medicine and Molecular Imaging
ISSN: 1619-7070
DOI: https://doi.org/10.1007/s00259-018-4194-x
URI: http://hdl.handle.net/10138/274090
Abstract: Objectives To evaluate the effect of pre-scan blood glucose levels (BGL) on standardized uptake value (SUV) in F-18-FDG-PET scan. Methods A literature review was performed in the MEDLINE, Embase, and Cochrane library databases. Multivariate regression analysis was performed on individual datum to investigate the correlation of BGL with SUVmax and SUVmean adjusting for sex, age, body mass index (BMI), diabetes mellitus diagnosis, F-18-FDG injected dose, and time interval. The ANOVA test was done to evaluate differences in SUVmax or SUVmean among five different BGL groups (200 mg/dl). Results Individual data for a total of 20,807 SUVmax and SUVmean measurements from 29 studies with 8380 patients was included in the analysis. Increased BGL is significantly correlated with decreased SUVmax and SUVmean in brain (p <0.001, p <0.001,) and muscle (p <0.001, p <0.001) and increased SUVmax and SUVmean in liver (p = 0.001, p = 0004) and blood pool (p=0.008, p200 mg/dl had significantly lower SUVmax. Conclusion If BGL is lower than 200mg/dl no interventions are needed for lowering BGL, unless the liver is the organ of interest. Future studies are needed to evaluate sensitivity and specificity of FDG-PET scan in diagnosis of malignant lesions in hyperglycemia.
Subject: 18F-FDG
PET scan
Blood glucose level
SUV
PET quantification
Diabetes mellitus
POSITRON-EMISSION-TOMOGRAPHY
SQUAMOUS-CELL CARCINOMA
LUNG-CANCER
DIABETIC-PATIENTS
BRAIN-BARRIER
TRANSPORTER
INSULIN
HYPERGLYCEMIA
METABOLISM
EXPRESSION
3126 Surgery, anesthesiology, intensive care, radiology
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