APOE epsilon 4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly Finns-Helsinki Birth Cohort Study

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Rantalainen , V , Lahti , J , Kajantie , E , Tienari , P , Eriksson , J G & Raikkonen , K 2019 , ' APOE epsilon 4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly Finns-Helsinki Birth Cohort Study ' , Neurobiology of Aging , vol. 73 , ARTN 230.e5 . https://doi.org/10.1016/j.neurobiolaging.2018.09.005

Title: APOE epsilon 4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly Finns-Helsinki Birth Cohort Study
Author: Rantalainen, Ville; Lahti, Jari; Kajantie, Eero; Tienari, Pentti; Eriksson, Johan G.; Raikkonen, Katri
Contributor: University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, University Management
University of Helsinki, Department of Neurosciences
University of Helsinki, Doctoral Programme in Clinical Research
University of Helsinki, Department of Psychology and Logopedics
Date: 2019-01
Language: eng
Number of pages: 4
Belongs to series: Neurobiology of Aging
ISSN: 0197-4580
URI: http://hdl.handle.net/10138/274092
Abstract: We tested if the epsilon 4 major isoform of the APOE gene and rs405509 and rs440446 promoter and intron-1 polymorphisms predicted risk of any dementia or Alzheimer's disease with diagnoses derived from the Hospital Discharge and Causes of Death Registers in 1453 participants of the Helsinki Birth Cohort Study. We used Cox proportional hazard models adjusted for sex, year of birth, maximum lifetime occupational status and education, and diagnoses of stroke, coronary heart disease, mood disorders, and depressive symptoms. APOE epsilon 4 predicted higher risk of any dementia (hazard ratios >3.68; 95% confidence interval [CI] 1.76, 7.70) across all statistical models, and when adjusted for rs405509 and rs440446. The number of minor alleles in rs405509 or rs440446 was not associated with dementia risk (hazard ratios
Subject: Dementia
Alzheimer's disease
APOE
Cohort studies
ALZHEIMERS-DISEASE
COGNITIVE CHANGE
GENE
METAANALYSIS
ASSOCIATION
GROWTH
REGION
ALLELE
AGE
515 Psychology
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