The Immunogenetic Conundrum of Preeclampsia

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Lokki , A I , Heikkinen-Eloranta , J K & Laivuori , H 2018 , ' The Immunogenetic Conundrum of Preeclampsia ' , Frontiers in Immunology , vol. 9 , 2630 . https://doi.org/10.3389/fimmu.2018.02630

Title: The Immunogenetic Conundrum of Preeclampsia
Author: Lokki, A. Inkeri; Heikkinen-Eloranta, Jenni K.; Laivuori, Hannele
Contributor organization: Immunobiology Research Program
Medicum
Research Programs Unit
University of Helsinki
Clinicum
Pregnancy and Genes
Department of Obstetrics and Gynecology
Institute for Molecular Medicine Finland
University Management
Department of Medical and Clinical Genetics
Helsinki Institute of Life Science HiLIFE
HUS Gynecology and Obstetrics
Genomics of Neurological and Neuropsychiatric Disorders
Date: 2018-11-13
Language: eng
Number of pages: 8
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2018.02630
URI: http://hdl.handle.net/10138/278420
Abstract: Pregnancy is an immunological challenge to the mother. The fetal tissues including the placenta must be protected from activation of the maternal immune system. On the other hand, the placental tissue sheds into the maternal circulation and must be adequately identified and phagocytized by the maternal immune system. During a healthy pregnancy, numerous immunosuppressive processes take place that allow the allograft fetus to thrive under exposure to humoral and cellular components of the maternal immune system. Breakdown of immune tolerance may result in sterile inflammation and cause adverse pregnancy outcomes such as preeclampsia, a vascular disease of the pregnancy with unpredictable course and symptoms from several organs. Immunological incompatibility between mother and fetus is strongly indicated in preeclampsia. Recently, genetic factors linking immunological pathways to predisposition to preeclampsia have been identified. In this mini-review genetic variation in immunological factors are discussed in the context of preeclampsia. Specifically, we explore immunogenetic and immunomodulary mechanisms contributing to loss of tolerance, inflammation, and autoimmunity in preeclampsia.
Subject: preeclampsia
genetics
complement
major histocompatibility complex
FLT1
autoimmunity
pregnancy
HEMOLYTIC-UREMIC SYNDROME
COFACTOR PROTEIN CD46
SYSTEMIC-LUPUS-ERYTHEMATOSUS
COMPLEMENT ACTIVATION
ANGIOGENIC FACTORS
EARLY GESTATION
MATERNAL KIR
HLA-G
PREGNANCY
CELLS
3123 Gynaecology and paediatrics
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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