Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis

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Hämetoja , H , Hirvonen , K , Hagström , J , Leivo , I , Saarilahti , K , Apajalahti , S , Haglund , C , Mäkitie , A & Bäck , L 2017 , ' Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis ' , Virchows Archiv , vol. 471 , no. 6 , pp. 785-792 . https://doi.org/10.1007/s00428-017-2163-6

Title: Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis
Author: Hämetoja, Hanna; Hirvonen, Karoliina; Hagström, Jaana; Leivo, Ilmo; Saarilahti, Kauko; Apajalahti, Satu; Haglund, Caj; Mäkitie, Antti; Bäck, Leif
Contributor organization: Department of Pathology
HUS Head and Neck Center
Translational Cancer Biology (TCB) Research Programme
Research Programs Unit
Department of Oncology
University of Helsinki
HUS Comprehensive Cancer Center
Department of Diagnostics and Therapeutics
HUS Medical Imaging Center
Department of Surgery
II kirurgian klinikka
HUS Abdominal Center
Department of Ophthalmology and Otorhinolaryngology
Korva-, nenä- ja kurkkutautien klinikka
Date: 2017-12
Language: eng
Number of pages: 8
Belongs to series: Virchows Archiv
ISSN: 0945-6317
DOI: https://doi.org/10.1007/s00428-017-2163-6
URI: http://hdl.handle.net/10138/279331
Abstract: The purpose of the study was to evaluate the long-term outcome of minor salivary and mucous gland (MiSG) adenoid cystic carcinoma (ACC) of the head and neck and to compare the results with earlier reports including our recently published series on major salivary gland (MaSG) ACC. The study comprised 68 MiSG ACCs operated during 1974-2012 at the Helsinki University Hospital, Helsinki, Finland. Medical records and histological samples were reviewed. Our previously published cohort comprising 54 MaSG ACCs during the years from 1974 to 2009 was used for comparison. The most common locations were the oral cavity and sinonasal cavities. Most patients presented stages IV (33.8%) and I (23.5%) disease. Primary treatment with curative intent, mainly surgery, was offered for 64 patients. Thirty-three (51.6%) of these patients developed a disease recurrence and 22 (66.7%) patients in less than 5 years. The difference in the length of recurrence-free time (<5 vs. > 5 years) had an impact on OS and DSS (p <0.001) showing worse prognosis for the earlier recurring group. T classes 2-4 (p = 0.005, p <0.001, and p = 0.001, respectively) and stages II-IV (p = 0.019, p <0.001, and p = 0.002, respectively) were associated with worse OS, DSS, and DFS. MiSG ACC had a similar long-term survival compared to MaSG ACC. Patients with stage I MiSG ACC seem to carry a favourable prognosis compared with those with stages II, III, and IV tumours. It is thus noteworthy that stage II tumours represent a truly advanced disease entity warranting a more aggressive treatment approach.
Subject: Adenoid cystic carcinoma
Minor salivary gland
Oral cancer
3111 Biomedicine
3122 Cancers
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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