Histamine H4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis - a short report

Show full item record




Salem , A , Almahmoudi , R , Listyarifah , D , Siponen , M , Maaninka , K A-L , Al-Samadi , A , Salo , T & Eklund , K K 2017 , ' Histamine H4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis - a short report ' , Cellular Oncology , vol. 40 , no. 6 , pp. 621-630 . https://doi.org/10.1007/s13402-017-0336-6

Title: Histamine H4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis - a short report
Author: Salem, Abdelhakim; Almahmoudi, Rabeia; Listyarifah, Dyah; Siponen, Maria; Maaninka, Katariina Anna-Liisa; Al-Samadi, Ahmed; Salo, Tuula; Eklund, Kari K.
Contributor organization: Clinicum
Invärtes medicin enhet
Department of Oral and Maxillofacial Diseases
Reumatologian yksikkö
Department of Medicine
HUS Head and Neck Center
HUS Internal Medicine and Rehabilitation
HUS Inflammation Center
Date: 2017-12
Language: eng
Number of pages: 10
Belongs to series: Cellular Oncology
ISSN: 1570-5870
DOI: https://doi.org/10.1007/s13402-017-0336-6
URI: http://hdl.handle.net/10138/282294
Abstract: Purpose: Recent reports indicate that histamine and its novel, high-affinity histamine H4 receptor (H4R) play a role in carcinogenesis, and thus H4R signalling has become a focus of increasing interest in the pathogenesis of many cancers. The roles of H4R in oral epithelial dysplasia (OED), and oral tongue squamous cell carcinomas (OTSCC) are unknown. The purpose of this study was to assess H4R expression in OTSCC patients and in cancer cell lines. Methods: Biopsies taken from OED, OTSCC, and healthy oral mucosa were studied by immunostaining. Primary human oral keratinocytes (HOKs) and two cancer cell lines (HSC-3 and SCC-25) were used for the in vitro studies. Quantitative real-time polymerase chain reaction was used to measure oncogene expression in the stimulated HOKs. Results: H4R-immunoreactivity was significantly reduced in OED and OTSCC samples, especially in the samples that had higher histopathological grades, which were also associated with noticeably increased mast cell counts. The presence of H4R in HSC-3 cells had clearly waned, in contrast to the HOKs. Gene expression data indicated that histamine-relevant inflammatory and environmental elements may participate in the regulation of some studied oncogenes. Conclusions: The results suggest a possible association between H4R and oral carcinogenesis. Furthermore, our findings raise a potential implication of histamine-mediated factors in the regulation of oncogenes, possibly via mast cells, as crucial components of tumor microenvironment. The identification of new elements that govern oral cancer development is highly important for the development of novel therapeutic approaches in OTSCC.
Subject: 3122 Cancers
Oral tongue squamous cell carcinoma
Oral cancer
Histamine H4 receptor
313 Dentistry
oral mucosa
Mast cell
oral pathology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
10.1007_s13402_017_0336_6.pdf 1.266Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record