Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes : prospective cohort study

Show full item record



Permalink

http://hdl.handle.net/10138/283166

Citation

Viskari , H , Oikarinen , S , Hoppu , S , Vuorinen , T , Huhtala , H , Toppari , J , Veijola , R , Ilonen , J , Knip , M & Hyoty , H 2018 , ' Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes : prospective cohort study ' , Diabetologia , vol. 61 , no. 1 , pp. 203-209 . https://doi.org/10.1007/s00125-017-4410-4

Title: Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes : prospective cohort study
Author: Viskari, Hanna; Oikarinen, Sami; Hoppu, Sanna; Vuorinen, Tytti; Huhtala, Heini; Toppari, Jorma; Veijola, Riitta; Ilonen, Jorma; Knip, Mikael; Hyoty, Heikki
Contributor: University of Helsinki, Clinicum
Date: 2018-01
Language: eng
Number of pages: 7
Belongs to series: Diabetologia
ISSN: 0012-186X
URI: http://hdl.handle.net/10138/283166
Abstract: Animal and human studies have implied that enterovirus infections may modulate the risk of islet autoimmunity and type 1 diabetes. We set out to assess whether serial administration of live oral poliovirus vaccine (OPV) in early life can influence the initiation of islet autoimmunity in a cohort of genetically predisposed children. OPV was administered to 64 children and a further 251 children received inactivated poliovirus vaccine (IPV). The emergence of type 1 diabetes-associated autoantibodies in serum (autoantibodies to GAD, insulinoma-associated protein 2, insulin and islet cells) was monitored during prospective follow-up. Stool and serum samples were collected for enterovirus detection by RT-PCR. Administration of OPV increased enterovirus detected in stool samples from 11.3% to 38.9% (p <0.001) during the first year of life. During the follow-up (median 11.0 years), at least one autoantibody was detected in 17.2% of children vaccinated with OPV and 19.1% with IPV (p = 0.723). At least two autoantibodies were observed in 3.1% and 6.8% of children, respectively (p = 0.384). Replication of attenuated poliovirus strains in gut mucosa is not associated with an increased risk of islet autoimmunity.
Subject: 3121 General medicine, internal medicine and other clinical medicine
Autoantibody
Enterovirus
Inactivated polio vaccine
Oral polio vaccine
Type 1 diabetes
RISK
AUTOANTIBODIES
INFECTIONS
CHILDHOOD
DETERMINANTS
PROGRESSION
APPEARANCE
LIFE
PCR
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
10.1007_s00125_017_4410_4.pdf 417.4Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record