High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection

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Mantula , P S , Outinen , T K , Jaatinen , P , Hämäläinen , M , Huhtala , H , Pörsti , I H , Vaheri , A , Mustonen , J T & Mäkelä , S M 2018 , ' High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection ' , PLoS One , vol. 13 , no. 12 , 0208017 . https://doi.org/10.1371/journal.pone.0208017

Titel: High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection
Författare: Mantula, Paula S.; Outinen, Tuula K.; Jaatinen, Pia; Hämäläinen, Mari; Huhtala, Heini; Pörsti, Ilkka H.; Vaheri, Antti; Mustonen, Jukka T.; Mäkelä, Satu M.
Upphovmannens organisation: Medicum
Department of Virology
University of Helsinki
Datum: 2018-12-05
Språk: eng
Sidantal: 14
Tillhör serie: PLoS One
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0208017
Permanenta länken (URI): http://hdl.handle.net/10138/285186
Abstrakt: Background Puumala hantavirus (PUUV) infected patients typically suffer from acute kidney injury (AKI). Adipokines have inflammation modulating functions in acute diseases including AKI. We examined plasma levels of three adipokines (resistin, leptin, and adiponectin) in acute PUUV infection and their associations with disease severity. Methods This study included 79 patients hospitalized due to acute PUUV infection. Plasma resistin, leptin, adiponectin, as well as IL-6 and CRP, were measured at the acute phase, recovery phase and one year after hospitalization. Results Plasma resistin levels were significantly higher in the acute phase compared to the recovery phase and one year after (median resistin 28 pg/mL (11-107) vs. 17 pg/mL (7-36) vs. 14 pg/mL (7-31), p= 353.6 mu mol/L) (OR 1.08, 95% CI 1.02-1.14). Neither plasma leptin nor adiponectin level had any correlation with creatinine concentration or the amount of albuminuria. Conclusions Plasma resistin independently associates with the severity of AKI in acute PUUV infection. The association of resistin with the amount of albuminuria suggests that the level of plasma resistin is not only influenced by renal clearance but could have some role in the pathogenesis of AKI during PUUV infection.
Subject: VIRUS NUCLEOCAPSID PROTEIN
NEPHROPATHIA-EPIDEMICA
INFLAMMATORY RESPONSE
LEPTIN
ADIPONECTIN
DISEASE
INTERLEUKIN-6
DEFICIENCY
ADIPOKINE
CORRELATE
3121 General medicine, internal medicine and other clinical medicine
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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