High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection

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dc.contributor.author Mantula, Paula S.
dc.contributor.author Outinen, Tuula K.
dc.contributor.author Jaatinen, Pia
dc.contributor.author Hämäläinen, Mari
dc.contributor.author Huhtala, Heini
dc.contributor.author Pörsti, Ilkka H.
dc.contributor.author Vaheri, Antti
dc.contributor.author Mustonen, Jukka T.
dc.contributor.author Mäkelä, Satu M.
dc.date.accessioned 2019-01-02T13:42:01Z
dc.date.available 2019-01-02T13:42:01Z
dc.date.issued 2018-12-05
dc.identifier.citation Mantula , P S , Outinen , T K , Jaatinen , P , Hämäläinen , M , Huhtala , H , Pörsti , I H , Vaheri , A , Mustonen , J T & Mäkelä , S M 2018 , ' High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection ' , PLoS One , vol. 13 , no. 12 , 0208017 . https://doi.org/10.1371/journal.pone.0208017
dc.identifier.other PURE: 120626063
dc.identifier.other PURE UUID: 91230294-a356-48db-9002-09aa4f3c26ee
dc.identifier.other WOS: 000452212400076
dc.identifier.other Scopus: 85057950372
dc.identifier.uri http://hdl.handle.net/10138/285186
dc.description.abstract Background Puumala hantavirus (PUUV) infected patients typically suffer from acute kidney injury (AKI). Adipokines have inflammation modulating functions in acute diseases including AKI. We examined plasma levels of three adipokines (resistin, leptin, and adiponectin) in acute PUUV infection and their associations with disease severity. Methods This study included 79 patients hospitalized due to acute PUUV infection. Plasma resistin, leptin, adiponectin, as well as IL-6 and CRP, were measured at the acute phase, recovery phase and one year after hospitalization. Results Plasma resistin levels were significantly higher in the acute phase compared to the recovery phase and one year after (median resistin 28 pg/mL (11-107) vs. 17 pg/mL (7-36) vs. 14 pg/mL (7-31), p= 353.6 mu mol/L) (OR 1.08, 95% CI 1.02-1.14). Neither plasma leptin nor adiponectin level had any correlation with creatinine concentration or the amount of albuminuria. Conclusions Plasma resistin independently associates with the severity of AKI in acute PUUV infection. The association of resistin with the amount of albuminuria suggests that the level of plasma resistin is not only influenced by renal clearance but could have some role in the pathogenesis of AKI during PUUV infection. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof PLoS One
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject VIRUS NUCLEOCAPSID PROTEIN
dc.subject NEPHROPATHIA-EPIDEMICA
dc.subject INFLAMMATORY RESPONSE
dc.subject LEPTIN
dc.subject ADIPONECTIN
dc.subject DISEASE
dc.subject INTERLEUKIN-6
dc.subject DEFICIENCY
dc.subject ADIPOKINE
dc.subject CORRELATE
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection en
dc.type Article
dc.contributor.organization Medicum
dc.contributor.organization Department of Virology
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1371/journal.pone.0208017
dc.relation.issn 1932-6203
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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