Human Bocavirus Infection Markers in Peripheral Blood and Stool Samples of Children with Acute Gastroenteritis

Show full item record



Permalink

http://hdl.handle.net/10138/286188

Citation

Nora-Krukle , Z , Vilmane , A , Xu , M , Rasa , S , Ziemele , I , Silina , E , Söderlund-Venermo , M , Gardovska , D & Murovska , M 2018 , ' Human Bocavirus Infection Markers in Peripheral Blood and Stool Samples of Children with Acute Gastroenteritis ' , Viruses-Basel , vol. 10 , no. 11 , 639 . https://doi.org/10.3390/v10110639

Title: Human Bocavirus Infection Markers in Peripheral Blood and Stool Samples of Children with Acute Gastroenteritis
Author: Nora-Krukle, Zaiga; Vilmane, Anda; Xu, Man; Rasa, Santa; Ziemele, Inga; Silina, Elina; Söderlund-Venermo, Maria; Gardovska, Dace; Murovska, Modra
Contributor: University of Helsinki, Doctoral Programme in Biomedicine
University of Helsinki, Department of Virology
Date: 2018-11
Language: eng
Number of pages: 9
Belongs to series: Viruses-Basel
ISSN: 1999-4915
URI: http://hdl.handle.net/10138/286188
Abstract: Human bocaviruses (HBoVs) 1-4 belong to the Parvoviridae family, and they infect the respiratory or gastrointestinal tracts in children. We investigated the prevalence of HBoV1-4 DNAs in the blood and stool samples, and of HBoV1-4 IgG and IgM in the plasma samples, of children presenting with acute gastroenteritis (AGE). In addition, we identified HBoV co-infections with the five most frequent gastrointestinal pathogens. A total of 83 paired blood and stool samples were collected from children aged five years or less. Infection markers of HBoV1, 2, or 3 (viral DNA in blood and/or stool and/or antibodies) were detected in 61 out of 83 (73.5%) patients. HBoV1, 2, or 3 DNA as a monoinfection was revealed in 18.1%, 2.4%, and 1.2%, respectively, and 21.7% in total. In 56.1% of the HBoV DNA-positive patients, the presence in stool of another virusmost frequently norovirus or rotaviruswas observed. In conclusion, this study, for the first time, illustrates the prevalence and genetic diversity of HBoVs in Latvian children with gastroenteritis, and shows a widespread distribution of these viruses in the community. HBoV1 and 2 are commonly found as single infectious agents in children with AGE, suggesting that the viruses can be as pathogenic by themselves as other enteric agents are.
Subject: human bocavirus
children
acute gastroenteritis
HOSPITALIZED CHILDREN
UNITED-STATES
HBOV
3111 Biomedicine
1183 Plant biology, microbiology, virology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
viruses_10_00639.pdf 234.8Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record