Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation

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http://hdl.handle.net/10138/287695

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Draper , L A , Ryan , F J , Smith , M K , Jalanka , J , Mattila , E , Arkkila , P , Ross , R P , Satokari , R & Hill , C 2018 , ' Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation ' , Microbiome , vol. 6 , 220 . https://doi.org/10.1186/s40168-018-0598-x

Titel: Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation
Författare: Draper, L. A.; Ryan, F. J.; Smith, M. K.; Jalanka, J.; Mattila, E.; Arkkila, P.; Ross, R. P.; Satokari, R.; Hill, C.
Upphovmannens organisation: Immunobiology Research Program
Department of Bacteriology and Immunology
Medicum
University of Helsinki
Research Programs Unit
Infektiosairauksien yksikkö
Department of Medicine
Clinicum
University Management
Gastroenterologian yksikkö
Reetta Maria Satokari / Principal Investigator
HUS Abdominal Center
HUS Internal Medicine and Rehabilitation
Datum: 2018-12-10
Språk: eng
Sidantal: 9
Tillhör serie: Microbiome
ISSN: 2049-2618
DOI: https://doi.org/10.1186/s40168-018-0598-x
Permanenta länken (URI): http://hdl.handle.net/10138/287695
Abstrakt: BackgroundFaecal microbiota transplantation (FMT) is used in the treatment of recurrent Clostridium difficile infection. Its success is typically attributed to the restoration of a diverse microbiota. Viruses (including bacteriophages) are the most numerically dominant and potentially the most diverse members of the microbiota, but their fate following FMT has not been well studied.ResultsWe studied viral transfer following FMT from 3 donors to 14 patients. Recipient viromes resembled those of their donors for up to 12months. Tracking individual bacteriophage colonisation revealed that engraftment of individual bacteriophages was dependent on specific donor-recipient pairings. Specifically, multiple recipients from a single donor displayed highly individualised virus colonisation patterns.ConclusionsThe impact of viruses on long-term microbial dynamics is a factor that should be reviewed when considering FMT as a therapeutic option.
Subject: Faecal microbiota transplantation
Bacteriophages
Viruses
Engraftment
Persistence
Donor-recipient
CLOSTRIDIUM-DIFFICILE INFECTION
HUMAN GUT VIROME
READ ALIGNMENT
3111 Biomedicine
1183 Plant biology, microbiology, virology
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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