Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation

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dc.contributor.author Draper, L. A.
dc.contributor.author Ryan, F. J.
dc.contributor.author Smith, M. K.
dc.contributor.author Jalanka, J.
dc.contributor.author Mattila, E.
dc.contributor.author Arkkila, P.
dc.contributor.author Ross, R. P.
dc.contributor.author Satokari, R.
dc.contributor.author Hill, C.
dc.date.accessioned 2019-01-07T15:17:01Z
dc.date.available 2019-01-07T15:17:01Z
dc.date.issued 2018-12-10
dc.identifier.citation Draper , L A , Ryan , F J , Smith , M K , Jalanka , J , Mattila , E , Arkkila , P , Ross , R P , Satokari , R & Hill , C 2018 , ' Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation ' , Microbiome , vol. 6 , 220 . https://doi.org/10.1186/s40168-018-0598-x
dc.identifier.other PURE: 120809743
dc.identifier.other PURE UUID: fad9233f-2096-43ac-bbc3-c3c651a3c08f
dc.identifier.other WOS: 000452729800001
dc.identifier.other Scopus: 85058316436
dc.identifier.other ORCID: /0000-0002-3847-8136/work/52392216
dc.identifier.uri http://hdl.handle.net/10138/287695
dc.description.abstract BackgroundFaecal microbiota transplantation (FMT) is used in the treatment of recurrent Clostridium difficile infection. Its success is typically attributed to the restoration of a diverse microbiota. Viruses (including bacteriophages) are the most numerically dominant and potentially the most diverse members of the microbiota, but their fate following FMT has not been well studied.ResultsWe studied viral transfer following FMT from 3 donors to 14 patients. Recipient viromes resembled those of their donors for up to 12months. Tracking individual bacteriophage colonisation revealed that engraftment of individual bacteriophages was dependent on specific donor-recipient pairings. Specifically, multiple recipients from a single donor displayed highly individualised virus colonisation patterns.ConclusionsThe impact of viruses on long-term microbial dynamics is a factor that should be reviewed when considering FMT as a therapeutic option. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Microbiome
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Faecal microbiota transplantation
dc.subject Bacteriophages
dc.subject Viruses
dc.subject Engraftment
dc.subject Persistence
dc.subject Donor-recipient
dc.subject 3111 Biomedicine
dc.subject 1183 Plant biology, microbiology, virology
dc.title Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation en
dc.type Article
dc.contributor.organization Immunobiology Research Program
dc.contributor.organization Department of Bacteriology and Immunology
dc.contributor.organization Medicum
dc.contributor.organization University of Helsinki
dc.contributor.organization Research Programs Unit
dc.contributor.organization Infektiosairauksien yksikkö
dc.contributor.organization Department of Medicine
dc.contributor.organization Clinicum
dc.contributor.organization University Management
dc.contributor.organization Gastroenterologian yksikkö
dc.contributor.organization Reetta Maria Satokari / Principal Investigator
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization HUS Internal Medicine and Rehabilitation
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1186/s40168-018-0598-x
dc.relation.issn 2049-2618
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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