High serum MMP-14 predicts worse survival in gastric cancer

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http://hdl.handle.net/10138/287696

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Kasurinen , A , Tervahartiala , T , Laitinen , A , Kokkola , A , Sorsa , T , Böckelman , C & Haglund , C 2018 , ' High serum MMP-14 predicts worse survival in gastric cancer ' , PLoS One , vol. 13 , no. 12 , 0208800 . https://doi.org/10.1371/journal.pone.0208800

Title: High serum MMP-14 predicts worse survival in gastric cancer
Author: Kasurinen, Aaro; Tervahartiala, Taina; Laitinen, Alli; Kokkola, Arto; Sorsa, Timo; Böckelman, Camilla; Haglund, Caj
Contributor: University of Helsinki, Translational Cancer Biology (TCB) Research Programme
University of Helsinki, Clinicum
University of Helsinki, Research Programs Unit
University of Helsinki, II kirurgian klinikka
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Clinicum
University of Helsinki, Translational Cancer Biology (TCB) Research Programme
Date: 2018-12-07
Language: eng
Number of pages: 11
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/287696
Abstract: Matrix metalloproteinases (MMPs), endopeptidases with diverse biochemical functions, can promote cancer cell invasion and metastasis by degrading the extracellular matrix. A high matrix metalloproteinase-14 (MMP-14) expression in gastric cancer tissue has been associated with metastasis and poor prognosis. To further understand this association, we investigated serum MMP-14 as a biomarker in gastric cancer patients. The patient cohort consisted of 240 gastric adenocarcinoma patients who underwent surgery at Helsinki University Hospital, Finland, between 2000 and 2009. We determined the soluble MMP-14 serum levels using an enzyme-linked immunosorbent assay. We then calculated the associations between serum levels and clinicopathologic variables using the Mann-Whitney U-test or the Kruskal-Wallis test. We constructed survival curves using the Kaplan-Meier method and calculating the hazard ratios using the Cox proportional hazard model. We revealed a positive association between a high serum MMP-14 level and stages III-IV (p = 0.029), and between a high serum MMP-14 and distant metastasis (p = 0.022). Patients with a low serum MMP-14 had a 5-year disease-specific survival of 49.2% (95% confidence interval [CI] 45.5-52.9), whereas patients with a high serum MMP-14 had a 5-year survival of 22.1% (95% CI 15.2-29.0; p = 0.001). High serum MMP-14 was a statistically significant prognostic factor among patients with an intestinal type of cancer (hazard ratio [HR] 3.54; 95% CI 1.51-8.33; p = 0.004), but not among patients with a diffuse type. The serum MMP-14 level remained an independent prognostic factor in our multivariate survival analysis (HR 1.55; 95% CI 1.02-2.35; p = 0.040). This study indicates for the first time that high serum soluble MMP-14 levels in gastric cancer serves as a marker for a poor prognosis, possibly indicating the presence of distant metastases.
Subject: MATRIX METALLOPROTEINASES
TUMOR INVASION
PRINOMASTAT
EXPRESSION
INHIBITOR
3122 Cancers
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