The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration

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Gasik , M , Zühlke , A , Haaparanta , A-M , Muhonen , V , Laine , K , Bilotsky , Y , Kellomäki , M & Kiviranta , I 2018 , ' The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration ' , Frontiers in Bioengineering and Biotechnology , vol. 6 , 187 . https://doi.org/10.3389/fbioe.2018.00187

Title: The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration
Author: Gasik, Michael; Zühlke, Alexandra; Haaparanta, Anne-Marie; Muhonen, Virpi; Laine, Kaisa; Bilotsky, Yevgen; Kellomäki, Minna; Kiviranta, Ilkka
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Surgery
Date: 2018-11-30
Language: eng
Number of pages: 11
Belongs to series: Frontiers in Bioengineering and Biotechnology
ISSN: 2296-4185
URI: http://hdl.handle.net/10138/288191
Abstract: Scaffolds for articular cartilage repair have to be optimally biodegradable with simultaneous promotion of hyaline cartilage formation under rather complex biomechanical and physiological conditions. It has been generally accepted that scaffold structure and composition would be the best when it mimics the structure of native cartilage. However, a reparative construct mimicking the mature native tissue in a healing tissue site presents a biological mismatch of reparative stimuli. In this work, we studied a new recombinant human type III collagen-polylactide (rhCol-PLA) scaffolds. The rhCol-PLA scaffolds were assessed for their relative performance in simulated synovial fluids of 1 and 4 mg/mL sodium hyaluronate with application of model-free analysis with Biomaterials Enhanced Simulation Test (BEST). Pure PLA scaffold was used as a control. The BEST results were compared to the results of a prior in vivo study with rhCol-PLA. Collectively the data indicated that a successful articular cartilage repair require lower stiffness of the scaffold compared to surrounding cartilage yet matching the strain compliance both in static and dynamic conditions. This ensures an optimal combination of load transfer and effective oscillatory nutrients supply to the cells. The results encourage further development of intelligent scaffold structures for optimal articular cartilage repair rather than simply trying to imitate the respective original tissue.
Subject: 318 Medical biotechnology
3126 Surgery, anesthesiology, intensive care, radiology
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