Risk Factors for Early-Onset Ischemic Stroke : A Case-Control Study

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Kivioja , R , Pietilä , A , Martinez-Majander , N , Gordin , D , Havulinna , A S , Salomaa , V , Aarnio , K , Curtze , S , Leiviskä , J , Rodriguez-Pardo , J , Surakka , I , Kaste , M , Tatlisumak , T & Putaala , J 2018 , ' Risk Factors for Early-Onset Ischemic Stroke : A Case-Control Study ' , Journal of the American Heart Association , vol. 7 , no. 21 , 009774 . https://doi.org/10.1161/JAHA.118.009774

Title: Risk Factors for Early-Onset Ischemic Stroke : A Case-Control Study
Author: Kivioja, Reetta; Pietilä, Arto; Martinez-Majander, Nicolas; Gordin, Daniel; Havulinna, Aki S.; Salomaa, Veikko; Aarnio, Karoliina; Curtze, Sami; Leiviskä, Jaana; Rodriguez-Pardo, Jorge; Surakka, Ida; Kaste, Markku; Tatlisumak, Turgut; Putaala, Jukka
Contributor organization: Department of Neurosciences
Clinicum
Neurologian yksikkö
University of Helsinki
Faculty of Medicine
Department of Medicine
Nefrologian yksikkö
Institute for Molecular Medicine Finland
HUSLAB
Samuli Olli Ripatti / Principal Investigator
HUS Neurocenter
HUS Abdominal Center
Complex Disease Genetics
Date: 2018-11-06
Language: eng
Number of pages: 9
Belongs to series: Journal of the American Heart Association
ISSN: 2047-9980
DOI: https://doi.org/10.1161/JAHA.118.009774
URI: http://hdl.handle.net/10138/288198
Abstract: Background-Recent studies have shown an increasing prevalence of vascular risk factors in young adults with ischemic stroke (IS). However, the strength of the association between all vascular risk factors and early-onset IS has not been fully established. Methods and Results-We compared 961 patients with a first-ever IS at 25 to 49 years to 1403 frequency-matched stroke-free controls from a population-based cohort study (FINRISK). Assessed risk factors included an active malignancy, atrial fibrillation, cardiovascular disease, current smoking status, a family history of stroke, high low-density lipoprotein cholesterol, high triglycerides, low high-density lipoprotein cholesterol, hypertension, and type 1 and type 2 diabetes mellitus. We performed subgroup analyses based on age, sex, and IS etiology. In a fully adjusted multivariable logistic regression analysis, significant risk factors for IS consisted of atrial fibrillation (odds ratio [OR], 10.43; 95% confidence interval [CI], 2.33-46.77], cardiovascular disease (OR, 8.01; 95% CI, 3.09-20.78), type 1 diabetes mellitus (OR, 6.72; 95% CI, 3.15-14.33), type 2 diabetes mellitus (OR, 2.31; 95% CI, 1.35-3.95), low high-density lipoprotein cholesterol (OR, 1.81; 95% CI, 1.37-2.40), current smoking status (OR, 1.81; 95% CI, 1.50-2.17), hypertension (OR, 1.43; 95% CI, 1.17-1.75), and a family history of stroke (OR, 1.37; 95% CI, 1.04-1.82). High low-density lipoprotein cholesterol exhibited an inverse association with IS. In the subgroup analyses, the most consistent associations appeared for current smoking status and type 1 diabetes mellitus. Conclusions-Our study establishes the associations between 11 vascular risk factors and early-onset IS, among which atrial fibrillation, cardiovascular disease, and both type 1 and 2 diabetes mellitus in particular showed strong associations.
Subject: brain infarction
middle-aged
risk factors
stroke
young adult
CERVICAL ARTERY DISSECTION
HIGH-DENSITY-LIPOPROTEIN
YOUNG-ADULTS
CEREBRAL INFARCTION
UNDETERMINED SOURCE
EMBOLIC STROKES
SMOKING
TRENDS
CLASSIFICATION
ASSOCIATION
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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