Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family

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http://hdl.handle.net/10138/288207

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Klymiuk , V , Yaniv , E , Huang , L , Raats , D , Fatiukha , A , Chen , S , Feng , L , Frenkel , Z , Krugman , T , Lidzbarsky , G , Chang , W , Jääskeläinen , M J , Schudoma , C , Paulin , L , Laine , P , Bariana , H , Sela , H , Saleem , K , Sorensen , C K , Hovmoller , M S , Distelfeld , A , Chalhoub , B , Dubcovsky , J , Korol , A B , Schulman , A H & Fahima , T 2018 , ' Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family ' , Nature Communications , vol. 9 , 3735 . https://doi.org/10.1038/s41467-018-06138-9

Title: Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family
Author: Klymiuk, Valentina; Yaniv, Elitsur; Huang, Lin; Raats, Dina; Fatiukha, Andrii; Chen, Shisheng; Feng, Lihua; Frenkel, Zeev; Krugman, Tamar; Lidzbarsky, Gabriel; Chang, Wei; Jääskeläinen, Marko J.; Schudoma, Christian; Paulin, Lars; Laine, Pia; Bariana, Harbans; Sela, Hanan; Saleem, Kamran; Sorensen, Chris Khadgi; Hovmoller, Mogens S.; Distelfeld, Assaf; Chalhoub, Boulos; Dubcovsky, Jorge; Korol, Abraham B.; Schulman, Alan H.; Fahima, Tzion
Contributor organization: Viikki teaching and research farm
Institute of Biotechnology
Viikki Plant Science Centre (ViPS)
Doctoral Programme in Plant Sciences
University Management
Date: 2018-10-03
Language: eng
Number of pages: 12
Belongs to series: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-018-06138-9
URI: http://hdl.handle.net/10138/288207
Abstract: Yellow rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a devastating fungal disease threatening much of global wheat production. Race-specific resistance (R)-genes are used to control rust diseases, but the rapid emergence of virulent Pst races has prompted the search for a more durable resistance. Here, we report the cloning of Yr15, a broad-spectrum R-gene derived from wild emmer wheat, which encodes a putative kinase-pseudokinase protein, designated as wheat tandem kinase 1, comprising a unique R-gene structure in wheat. The existence of a similar gene architecture in 92 putative proteins across the plant kingdom, including the barley RPG1 and a candidate for Ug8, suggests that they are members of a distinct family of plant proteins, termed here tandem kinase-pseudokinases (TKPs). The presence of kinase-pseudokinase structure in both plant TKPs and the animal Janus kinases sheds light on the molecular evolution of immune responses across these two kingdoms.
Subject: F-SP TRITICI
STRIPE RUST
PUCCINIA-STRIIFORMIS
DISEASE-RESISTANCE
IMMUNE RECEPTORS
HEXAPLOID WHEAT
EVOLUTION
PATHOGEN
GENOME
DIVERSITY
1183 Plant biology, microbiology, virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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