Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family

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http://hdl.handle.net/10138/288207

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Klymiuk , V , Yaniv , E , Huang , L , Raats , D , Fatiukha , A , Chen , S , Feng , L , Frenkel , Z , Krugman , T , Lidzbarsky , G , Chang , W , Jääskeläinen , M J , Schudoma , C , Paulin , L , Laine , P , Bariana , H , Sela , H , Saleem , K , Sorensen , C K , Hovmoller , M S , Distelfeld , A , Chalhoub , B , Dubcovsky , J , Korol , A B , Schulman , A H & Fahima , T 2018 , ' Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family ' , Nature Communications , vol. 9 , 3735 . https://doi.org/10.1038/s41467-018-06138-9

Title: Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family
Author: Klymiuk, Valentina; Yaniv, Elitsur; Huang, Lin; Raats, Dina; Fatiukha, Andrii; Chen, Shisheng; Feng, Lihua; Frenkel, Zeev; Krugman, Tamar; Lidzbarsky, Gabriel; Chang, Wei; Jääskeläinen, Marko J.; Schudoma, Christian; Paulin, Lars; Laine, Pia; Bariana, Harbans; Sela, Hanan; Saleem, Kamran; Sorensen, Chris Khadgi; Hovmoller, Mogens S.; Distelfeld, Assaf; Chalhoub, Boulos; Dubcovsky, Jorge; Korol, Abraham B.; Schulman, Alan H.; Fahima, Tzion
Contributor: University of Helsinki, Viikki teaching and research farm
University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology
University of Helsinki, Doctoral Programme in Plant Sciences
Date: 2018-10-03
Language: eng
Number of pages: 12
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/288207
Abstract: Yellow rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a devastating fungal disease threatening much of global wheat production. Race-specific resistance (R)-genes are used to control rust diseases, but the rapid emergence of virulent Pst races has prompted the search for a more durable resistance. Here, we report the cloning of Yr15, a broad-spectrum R-gene derived from wild emmer wheat, which encodes a putative kinase-pseudokinase protein, designated as wheat tandem kinase 1, comprising a unique R-gene structure in wheat. The existence of a similar gene architecture in 92 putative proteins across the plant kingdom, including the barley RPG1 and a candidate for Ug8, suggests that they are members of a distinct family of plant proteins, termed here tandem kinase-pseudokinases (TKPs). The presence of kinase-pseudokinase structure in both plant TKPs and the animal Janus kinases sheds light on the molecular evolution of immune responses across these two kingdoms.
Subject: F-SP TRITICI
STRIPE RUST
PUCCINIA-STRIIFORMIS
DISEASE-RESISTANCE
IMMUNE RECEPTORS
HEXAPLOID WHEAT
EVOLUTION
PATHOGEN
GENOME
DIVERSITY
1183 Plant biology, microbiology, virology
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