Late vertebral side effects in long-term survivors of irradiated childhood brain tumor

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Jussila , M-P , Remes , T , Anttonen , J , Harila-Saari , A , Niinimäki , J , Pokka , T , Koskenkorva , P , Sutela , A , Toiviainen-Salo , S , Arikoski , P , Riikonen , P , Arola , M , Lähteenmäki , P , Sirkiä , K , Rantala , H , Suo-Palosaari , M & Ojaniemi , M 2018 , ' Late vertebral side effects in long-term survivors of irradiated childhood brain tumor ' , PLoS One , vol. 13 , no. 12 , 0209193 . https://doi.org/10.1371/journal.pone.0209193

Title: Late vertebral side effects in long-term survivors of irradiated childhood brain tumor
Author: Jussila, Miro-Pekka; Remes, Tiina; Anttonen, Julia; Harila-Saari, Arja; Niinimäki, Jaakko; Pokka, Tytti; Koskenkorva, Päivi; Sutela, Anna; Toiviainen-Salo, Sanna; Arikoski, Pekka; Riikonen, Pekka; Arola, Mikko; Lähteenmäki, Päivi; Sirkiä, Kirsti; Rantala, Heikki; Suo-Palosaari, Maria; Ojaniemi, Marja
Contributor organization: Department of Diagnostics and Therapeutics
Clinicum
University of Helsinki
Children's Hospital
HUS Medical Imaging Center
HUS Children and Adolescents
Date: 2018-12-18
Language: eng
Number of pages: 14
Belongs to series: PLoS One
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0209193
URI: http://hdl.handle.net/10138/288725
Abstract: Purpose Long-term side effects of the treatments are common in survivors of irradiated pediatric brain tumors. Ionizing radiation in combination with surgery and chemotherapy during childhood may reduce vertebral height and bone mineral density (BMD), and cause growth failure. The aim of this study was to evaluate the late consequences of tumor treatments on vertebrae in survivors of childhood brain tumors. Methods 72 adult survivors (mean age 27.8 years, standard deviation 6.7) of irradiated childhood brain tumor were studied by spinal magnetic resonance imaging (MRI) for vertebral abnormalities from the national cohort of Finland. Patients were treated in five university hospitals in Finland between the years 1970 and 2008. Subject height and weight were measured and body mass index (BMI) was calculated. The morphology and height/ depth ratio of the vertebrae in the middle of the kyphotic thoracic curvature (Th8) and lumbar lordosis (L3) were examined. Vertebrae were analyzed by Genant's semiquantative (SQ) method and spinal deformity index (SDI) was calculated. BMD was measured by using dual X-ray absorptiometry. Results 4.2% (3/72) of the patients had undiagnosed asymptomatic vertebral fracture and 5.6% (4/72) of patients had radiation- induced decreased vertebral body height. Male patients had flatter vertebrae compared with females. Patient age at the time of irradiation, BMI and irradiation area correlated to vertebral morphology differentially in males and females. BMD had no association with the vertebral shape. Patients who had received craniospinal irradiation were shorter than the general population. Conclusion Childhood brain tumor survivors had a high number of vertebral abnormalities in young adulthood. Irradiation was associated with abnormal vertebral morphology and compromised final height. Male gender may predispose vertebrae to the side effects of irradiation.
Subject: BONE-MINERAL DENSITY
GROWTH-HORMONE
RADIATION-THERAPY
ADULT SURVIVORS
FRACTURES
ENDOCRINE
HEALTH
MASS
3123 Gynaecology and paediatrics
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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